Downregulation of Candidate Gene Expression and Neuroprotection by Piperine in Streptozotocin-Induced Hyperglycemia and Memory Impairment in Rats.
Suresh Kumar,Suman Chowdhury,Ajay Razdan,Deepa Kumari,Ram Singh Purty,Heera Ram,Pramod Kumar,Prasunpriya Nayak,Sunil Shukla +8 more
TLDR
In this paper, the authors evaluated the effect of piperine on Alzheimer's disease in diabetic rats and showed that piperines not only improved memory but also reduced the expression of specific AD-related genes.Abstract:
There is accumulating evidence showing that hyperglycemia conditions like diabetes possess a greater risk of impairment to the neuronal system because high glucose levels exacerbate oxidative stress, accumulation of amyloid-beta peptides, and mitochondrial dysfunction, and impair cognitive functions and cause neurodegeneration conditions like Alzheimer's diseases. Due to the extensive focus on pharmacological intervention to prevent neuronal cells' impairment induced by hyperglycemia, the underlying molecular mechanism that links between Diabetes and Alzheimer's is still lacking. Given this, the present study aimed to evaluate the protective effect of piperine on streptozotocin (STZ) induced hyperglycemia and candidate gene expression. In the present study, rats were divided into four groups: control (Vehicle only), diabetic control (STZ only), piperine treated (20 mg/kg day, i.p), and sitagliptin (Positive control) treated. The memory function was assessed by Morris water maze and probe test. After treatment, biochemical parameters such as HOMA index and lipid profile were estimated in the serum, whereas histopathology was evaluated in pancreatic and brain tissue samples. Gene expression studies were done by real-time PCR technique. Present data indicated that piperine caused significant memory improvement as compared to diabetic (STZ) control. The assessment of HOMA indices in serum samples showed that piperine and sitagliptin (positive control, PC) caused significant alterations of insulin resistance, β cell function, and insulin sensitivity. Assessment of brain and pancreas histopathology shows significant improvement in tissue architecture in piperine and sitagliptin treated groups compared to diabetic control. The gene expression profile in brain tissue shows significantly reduced BACE1, PSEN1, APAF1, CASPASE3, and CATALASE genes in the piperine and sitagliptin (PC) treated groups compared to Diabetic (STZ) control. The present study demonstrated that piperine not only improves memory in diabetic rats but also reduces the expression of specific AD-related genes that can help design a novel strategy for therapeutic intervention at the molecular level.read more
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Piperine and Its Metabolite’s Pharmacology in Neurodegenerative and Neurological Diseases
TL;DR: This study aims to combine the current knowledge of PIP pharmacology and biochemistry with neurodegenerative and neurological disease therapy, and suggests that its several metabolites are reactive and plausibly responsible for acute toxicity or have pharmacological potentiality.
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Hypoglycemic medicines in the treatment of Alzheimer’s disease: Pathophysiological links between AD and glucose metabolism
TL;DR: In this paper , the authors summarized the pharmacological mechanism of hypoglycemic drugs and herbal medicines, focusing on glucose metabolism, and concluded that polyphenols, alkaloids, glycosides, and flavonoids have protective benefits in cognition function and glucose metabolism.
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Germinated millet flour (Pennisetum glaucum (L.) R. BR.) improves adipogenesis and glucose metabolism and maintains thyroid function in vivo
Jaqueline Maciel Vieira Theodoro,Oscar David Medina Martinez,Mariana Grancieri,Renata Celi Lopes Toledo,Mirella Lima Binoti,Amanda Mattos Dias Martins,Carlos Wanderlei Piler de Carvalho,Patricia Cristina Lisboa,Hércia Stampini Duarte Martino +8 more
TL;DR: In this paper, the effects of germinated millet flour on adipogenesis, insulin resistance, glucose tolerance and thyroid function in Wistar rats fed with a high-fat high-fructose diet (HFHF) were investigated.
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Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations
A. Uba,Gokhan Zengin +1 more
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Altered hallmarks of DNA double-strand breaks, oxidative DNA damage and cytogenotoxicity by piperlongumine in hippocampus and hepatocytes of rats intoxicated with cyclophosphamide.
TL;DR: Piperlongumine (50 mg/kg) was co-administered with cyclophosphamide for 28 days to Wistar albino rats as discussed by the authors , which significantly reversed genotoxicity in high-proliferation tissue (bone marrow: p < 0.05), calculated as micronuclei formation and %DNA fragmentation.
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