Journal ArticleDOI
Dr. Jekyll and Mr. Hyde: a short history of anthrax.
TLDR
The anthrax letters crisis, following the discovery of a major bacterial warfare program in the USSR and the realization that Irak had been on the verge of using anthrax as a weapon during the first Gulf war, had the consequence of putting anthrax back on the agenda of scientists.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2009-12-01. It has received 55 citations till now. The article focuses on the topics: Anthrax vaccines & Bacillus anthracis.read more
Citations
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Journal ArticleDOI
Drug Interactions with Bacillus anthracis Topoisomerase IV: Biochemical Basis for Quinolone Action and Resistance
Katie J. Aldred,Sylvia A. McPherson,Pengfei Wang,Robert J. Kerns,David E. Graves,Charles L. Turnbough,Neil Osheroff +6 more
TL;DR: 8-Methyl-quinazoline-2,4-dione was more potent than quinolones against wild-type topoisomerase IV and was equally efficacious, and maintained high potency and efficacy against the mutant enzymes, effectively inhibited DNA religation, and formed stable ternary complexes.
Journal ArticleDOI
New insights into the biological effects of anthrax toxins: linking cellular to organismal responses.
TL;DR: The various biological effects of anthrax toxins are examined, focusing on the fulminant stage of the disease and on mechanisms by which the two toxins may collaborate to cause cardiovascular collapse, which will cause death even when the bacterial proliferation is curtailed by antibiotics.
Journal ArticleDOI
A genomic map of climate adaptation in Mediterranean cattle breeds
Laurence Flori,Katayoun Moazami-Goudarzi,Véronique Alary,Véronique Alary,Abdelillah Araba,Ismaïl Boujenane,Nadjet Boushaba,François Casabianca,Sara Casu,Roberta Ciampolini,Armelle Coeur D'Acier,Corinne Coquelle,J. V. Delgado,Ahmed El‐Beltagi,Georgia Hadjipavlou,Emmanuelle Jousselin,Vincenzo Landi,Anne Lauvie,Philippe Lecomte,Christina Ligda,Caroline Marinthe,Amparo Martínez Martínez,Salvatore Mastrangelo,Dalal Menni,Charles-Henri Moulin,Mona-Abdelzaher Osman,Olivier Pineau,Baldassare Portolano,Clementina Rodellar,Nadhira Saïdi-Mehtar,Tiziana Sechi,Guilhem Sempere,Sophie Thevenon,Dimitrios Tsiokos,Denis Laloë,Mathieu Gautier +35 more
TL;DR: In this article, using newly generated dense SNP genotyping data, the authors assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome-wide association analyses with covariables discriminating the different Mediterranean climate subtypes.
Journal ArticleDOI
Investigation of antimicrobial activity of photothermal therapeutic gold/copper sulfide core/shell nanoparticles to bacterial spores and cells
TL;DR: It was found that Au/CuS NPs were highly efficient in inactivating B. anthracis cells, but not effective to the spores, while the antimicrobial effect was both NPs concentration and treatment time dependent.
References
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Journal ArticleDOI
Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor
Nicholas S. Duesbery,Craig P. Webb,Stephen H. Leppla,Valery M. Gordon,Kurt Klimpel,Terry D. Copeland,Natalie G. Ahn,M Oskarsson,Kenji Fukasawa,Ken D. Paull,George F. Vande Woude +10 more
TL;DR: It is shown that LF is a protease that cleaves the amino terminus of mitogen-activated protein kinase kinases 1 and 2 and that this cleavage inactivates MAPKK1 and inhibits the MAPK signal transduction pathway.
Journal ArticleDOI
Anthrax as a biological weapon, 2002: updated recommendations for management.
Thomas V. Inglesby,Tara O'Toole,Donald A. Henderson,John G. Bartlett,Michael S. Ascher,Edward M. Eitzen,Arthur M. Friedlander,Julie L. Gerberding,Jerome Hauer,James M. Hughes,Joseph E. McDade,Michael T. Osterholm,Gerald W. Parker,Trish M. Perl,Philip K. Russell,Kevin Tonat +15 more
TL;DR: This revised consensus statement presents new information based on the analysis of the anthrax attacks of 2001, including developments in the investigation of the Anthrax Attacks of 2001; important symptoms, signs, and laboratory studies; new diagnostic clues that may help future recognition of this disease; updated antibiotic therapeutic considerations; and judgments about environmental surveillance and decontamination.
Journal ArticleDOI
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.
TL;DR: It is shown here that EF is an adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1] produced by Bacillus anthracis in an inactive form and nearly equals that of the most active known cyclase.
Journal ArticleDOI
The Sverdlovsk anthrax outbreak of 1979
Matthew Meselson,Jeanne Guillemin,Martin Hugh-Jones,Alexander Langmuir,Ilona Popova,Alexis Shelokov,Olga Yampolskaya +6 more
TL;DR: It is concluded that the escape of an aerosol of anthrax pathogen at the military facility caused the outbreak of Sverdlovsk and that most victims worked or lived in a narrow zone extending from a military facility to the southern city limit.
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Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings.
Daniel B. Jernigan,Pratima L Raghunathan,Beth P. Bell,Ross J. Brechner,Eddy A. Bresnitz,Jay C. Butler,Marty Cetron,Mitch Cohen,Timothy J. Doyle,Marc Fischer,Carolyn M. Greene,Kevin S. Griffith,Jeannette Guarner,James L. Hadler,James A. Hayslett,Richard D. Meyer,Lyle R. Petersen,Michael R. Phillips,Robert W. Pinner,Tanja Popovic,Conrad P. Quinn,Jennita Reefhuis,Dori B. Reissman,Nancy E. Rosenstein,Anne Schuchat,Wun-Ju Shieh,Larry Siegal,David L. Swerdlow,Fred C. Tenover,Marc S. Traeger,John W. Ward,Isaac B. Weisfuse,Steven T. Wiersma,Kevin Yeskey,Sherif R. Zaki,David A. Ashford,Bradley A. Perkins,Steve Ostroff,James M. Hughes,David W. Fleming,Jeffrey P. Koplan,Julie L. Gerberding +41 more