Journal ArticleDOI
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
Jurgen M.J. Piek,P. J. Van Diest,Ronald P. Zweemer,J W Jansen,Ria J.J. Poort-Keesom,Fred H. Menko,Johan J.P. Gille,A P M Jongsma,Gerard Pals,Peter Kenemans,R Verheijen +10 more
TLDR
The Fallopian tubes of women predisposed to developing ovarian cancer frequently harbour dysplastic changes, accompanied by changes in cell‐cycle and apoptosis‐related proteins, indicating an increased risk of developing tubal cancer.Abstract:
The aim of this study was to investigate the occurrence of (pre)neoplastic lesions in overtly normal Fallopian tubes from women predisposed to developing ovarian carcinoma. The presence of (pre)neoplastic lesions was scored in histological specimens from 12 women with a genetically determined predisposition for ovarian cancer, of whom seven tested positive for a germline BRCA1 mutation. A control group included 13 women. Immunohistochemistry was used to determine the expression of p21, p27, p53, cyclin A, cyclin D1, bcl-2, Ki67, HER-2/neu, and the oestrogen and progesterone receptors. Loss of heterozygosity (LOH) analysis on the BRCA1 locus was also assessed on dysplastic tissue by PCR studies. Of the 12 women with a predisposition for ovarian cancer, six showed dysplasia, including one case of severe dysplasia. Five harboured hyperplastic lesions and in one woman no histological aberrations were found in the Fallopian tube. No hyperplastic, dysplastic or neoplastic lesions were detected in the Fallopian tubes of control subjects. In the cases studied, morphologically normal tubal epithelium contained a higher proportion of Ki67-expressing cells (p=0.005) and lower fractions of cells expressing p21 (p<0.0001) and p27 (p=0.006) than in the control group. Even higher fractions of proliferating cells were found in dysplastic areas (p=0.07) and accumulation of p53 was observed in the severely dysplastic lesion. Expression patterns of other proteins studied, including the hormone receptors, were similar in cases and controls. One subject, a germline BRCA1 mutation carrier, showed loss of the wild-type BRCA1 allele in the severely dysplastic lesion. In conclusion, the Fallopian tubes of women predisposed to developing ovarian cancer frequently harbour dysplastic changes, accompanied by changes in cell-cycle and apoptosis-related proteins, indicating an increased risk of developing tubal cancer.read more
Citations
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Journal ArticleDOI
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Robert J. Kurman,Ie Ming Shih +1 more
TL;DR: It has been proposed that serous tumors arise from the implantation of epithelium (benign or malignant) from the fallopian tube and preliminary data suggest that mucinous and transitional (Brenner) tumors arose from transitional-type epithelial nests at the tubal-mesothelial junction by a process of metaplasia.
Journal ArticleDOI
Ovarian Cancer Development and Metastasis
TL;DR: The initial steps of metastasis are regulated by a controlled interaction of adhesion receptors and proteases, and late metastasis is characterized by the oncogene-driven fast growth of tumor nodules on mesothelium covered surfaces, causing ascites, bowel obstruction, and tumor cachexia.
Journal ArticleDOI
Rethinking ovarian cancer: recommendations for improving outcomes
Sebastian Vaughan,Jermaine Coward,Robert C. Bast,Andrew Berchuck,Jonathan S. Berek,James D. Brenton,George Coukos,Christopher C. Crum,Ronny Drapkin,Dariush Etemadmoghadam,Michael Friedlander,Hani Gabra,Stan B. Kaye,Christopher J. Lord,Ernst Lengyel,Douglas A. Levine,Iain A. McNeish,Usha Menon,Gordon B. Mills,Kenneth P. Nephew,Amit M. Oza,Anil K. Sood,Euan A. Stronach,Henning Walczak,David D.L. Bowtell,Frances R. Balkwill +25 more
TL;DR: Nine major recommendations that should be taken to improve the outcome for women with ovarian cancer are outlined in this Opinion article.
Journal ArticleDOI
Staging classification for cancer of the ovary, fallopian tube, and peritoneum
TL;DR: The FIGO Committee on Gynecologic Oncology feels that it is time to revise this classification to improve utility and reproducibility.
Journal ArticleDOI
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm
Robert J. Kurman,Ie Ming Shih +1 more
TL;DR: It now appears that type I and type II ovarian tumors develop independently along different molecular pathways and that both types develop outside the ovary and involve it secondarily, leading to the conclusion that the only true primary ovarian neoplasms are gonadal stromal and germ cell tumors analogous to testicular tumors.
References
More filters
Journal ArticleDOI
Cancer-susceptibility genes. Gatekeepers and caretakers
Journal ArticleDOI
Laser capture microdissection in pathology
Falko Fend,Mark Raffeld +1 more
TL;DR: Laser capture microdissection (LCM) is state-of-the-art technology that provides the scientific community with a rapid and reliable method to isolate a homogeneous population of cells from heterogeneous tissue specimens, thus providing investigators with the ability to analyze DNA, RNA, and protein accurately from pure populations of cells.
Journal ArticleDOI
Primary carcinoma of the fallopian tube.
C.Y. Hu,M.L. Taymor,A.T. Hertig +2 more
TL;DR: At the Free Hospital for Women there have been twelve primary carcinomas of the Fallopian tube out of 3,878 primary malignant lesions of the female genital tract in the 90,611 admissions from 1903 to 1948, an incidence of 0.31 per cent ofPrimary malignant tumors.
Journal ArticleDOI
A scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group.
P. J. Van Diest,P. van Dam,S.C. Henzen-Logmans,E. Berns,M. E. L. Van Der Burg,J. Green,I. Vergote +6 more
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