Journal ArticleDOI
Effect of exogenous melatonin on X-ray induced cellular toxicity in lymphatic tissue of Indian tropical male squirrel, Funambulus pennanti.
TLDR
Exogenous melatonin with its anti-apoptotic and antioxidant properties additively increased the immunity of the squirrels, by protecting their hematopoietic system and lymphoid organs against X-ray radiation induced cellular toxicity.Abstract:
Purpose: The radioprotective ability of melatonin was investigated in the Indian tropical rodent, Funambulus pennanti during its reproductively inactive phase (RIP) when peripheral melatonin is high and the animal is under the influence of environmental stresses. Materials and methods: Fifty male squirrels were divided into two sets of 25 each; with set 1 receiving 0.9% saline and set 2 receiving 25 mg melatonin/100 g body weight/day for four weeks during evening hours. Five saline-treated and five-melatonin treated squirrels were sacrificed at times of 4, 24, 48 and 72 hours following 2.06 Gy X-ray radiation. Remaining squirrels that were not exposed to X-ray were used as control and melatonin treated, respectively. Total leukocyte count (TLC) and lymphocyte count (LC) in peripheral blood and lipid peroxidation (LPO) status, superoxide dismutase (SOD) activity, total antioxidant status (TAS), apoptotic percentage on the basis of morphological changes and DNA fragmentation and caspase3 activity were measured in the spleens of squirrels. Results: Peripheral blood and spleens with higher intrinsic levels of environmental and X-radiation induced free radical generation had inhibited TLC, LC, SOD activity and TAS and increased LPO and apoptosis. Melatonin pre-treatment significantly reduced and altered the changes brought on by X-radiation. Conclusion: Exogenous melatonin with its anti-apoptotic and antioxidant properties additively increased the immunity of the squirrels, by protecting their hematopoietic system and lymphoid organs against X-ray radiation induced cellular toxicity.read more
Citations
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Journal Article
The Evaluation of Melatonin Effect Against The Early Effect of Ionizing Radiation Induced Lung Injury
TL;DR: Melatonin can prevent early damages in irradiated lungs according to the results, and can directly decrease the radiation induced cell damages by converting the free radicals to nontoxic compounds and also through the activation of the major antioxidant enzymes.
Journal ArticleDOI
Roles of free radicals in reproduction and immune modulations in goats: A review
TL;DR: Monsoon and winter are the seasons of stress for both the sexes of goats as suggested by elevated level of glucocorticoid receptor and thus to counteract the elevated stress level melatonin acted as a “coupler” which not only increased the free radical scavenging enzymes but also scavenged free radicals as an amphipatic free molecules particularly during winter.
Comparative effects of various antioxidants on the hematological changes during radiotherapy of iraqi females with breast cancer
Rouia Abdulrazaq Abulkassim,Dawsar Khalil Ismael,Nawfal Abdulmonem Numan,Nada N. Al-Shawi,Saad Abdulrahman Hussain +4 more
TL;DR: In women with breast cancer, Hb, WBCs counts and platelets levels decreases lower than that of normal controls, and radiation therapy further decreases these parameters, indicating that the use of antioxidant drugs may have some protective effects against damaging effects of radiation therapy.
Journal ArticleDOI
Daily variation in antioxidant enzymes lipid peroxidation in thyroid and plasma level thyroxine and triiodothyronine levels of a tropical bird Perdicula asiatica during reproductively active and inactive phases
TL;DR: Overall, melatonin and thyroid circadian profile suggested that melatonin might be acting as an antioxidant molecule with time of the day effect in rescuing thyroid gland from free radical load in birds.
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Antioxidant and cytoprotective effect of melatonin on hepatotoxicity and oxidative stress induced by orange yellow s in male rats
TL;DR: The results support the use of supplemental melatonin as a modulating antioxidant agent in reducing the cytotoxic effect induced by the food colour additive Orange Yellow S in male rats.
References
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Roberta Re,Nicoletta Pellegrini,Anna R. Proteggente,Ananth S. Pannala,Min Yang,Catherine Rice-Evans +5 more
TL;DR: A method for the screening of antioxidant activity is reported as a decolorization assay applicable to both lipophilic and hydrophilic antioxidants, including flavonoids, hydroxycinnamates, carotenoids, and plasma antioxidants.
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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
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Regulation of antioxidant enzymes: a significant role for melatonin.
Carmen Rodríguez,Juan C. Mayo,Rosa M. Sainz,Isaac Antolín,Federico Herrera,Vanesa Martín,Russel J. Reiter +6 more
TL;DR: This report reviews the studies which document the influence of melatonin on the activity and expression of the antioxidative enzymes glutathione peroxidase, superoxide dismutases and catalase both under physiological and under conditions of elevated oxidative stress and analyses the possible mechanisms by which melatonin regulates these enzymes.
Journal ArticleDOI
Actions of melatonin in the reduction of oxidative stress
TL;DR: Melatonin was discovered to be a direct free radical scavenger less than 10 years ago and besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species, it stimulates several antioxidative enzymes which increase its efficiency as an antioxidant.