Journal ArticleDOI
Effect of low-level lead exposure on antibody-dependent and natural killer cell-mediated cytotoxicity
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TLDR
It is suggested that chronic low-level lead exposure in mice results in significant suppression of ADCC (CRBC) but does not alter natural killer activity.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1983-06-30. It has received 19 citations till now. The article focuses on the topics: Lead acetate & Antibody-dependent cell-mediated cytotoxicity.read more
Citations
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Journal ArticleDOI
Lead and immune function.
TL;DR: This review considers the animal and human evidence that lead exposure can produce a stark shift in immune functional capacity with a skewing predicted to elevate the risk of atopic and certain autoimmune diseases.
Journal ArticleDOI
Immunotoxicology: suppressive and stimulatory effects of drugs and environmental chemicals on the immune system - A discussion
TL;DR: The objective of the meeting from which this report derives was to examine what sources of information are available, and what experimental protocols can be employed, to permit accurate evaluation of immunological reserve, to review the current state of knowledge regarding drug- and chemical-induced autoimmunity.
Journal ArticleDOI
A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats.
Nuran Ercal,Rachel Neal,Piyanee Treeratphan,Paula Lutz,Terese C. Hammond,Phyllis A. Dennery,Douglas R. Spitz +6 more
TL;DR: It is suggested that oxidative stress contributes to suppressed serum Ig levels during lead intoxication in vivo, and that intervention with either a thiol antioxidant (NAC) or a metal chelator (DMSA) will alleviate this lead-induced suppression by correcting the prooxidant/antioxidant imbalance caused by lead exposure.
Journal ArticleDOI
Effect of lead exposure on the immune response of some occupationally exposed individuals
Kamla Prasad Mishra,Vijay K. Singh,Reena Rani,V S Yadav,Vinod Chandran,Satya P. Srivastava,Prahlad K. Seth +6 more
TL;DR: It is demonstrated that lead can affect the immune response of the occupationally exposed individuals such as three-wheeler drivers, battery reconditioning workers and silver jewelery makers.
Journal ArticleDOI
Oxidative stress and immunotoxic effects of lead and their amelioration with myrrh (Commiphora molmol) emulsion.
TL;DR: CME is a potent antioxidant, and can protect against PbAc-induced hepatic oxidative damage and immunotoxicity by reducing lipid peroxidation and enhancing the antioxidant and immune defense mechanisms.
References
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Book ChapterDOI
Natural Cell-Mediated Immunity
TL;DR: This chapter summarizes the known information on the expression of natural cytotoxicity in rodents and in man, its specificity, the nature of the effector cells and their relationship to other immune mechanisms, and the possible in vivo relevance ofnatural cytotoxic relevance, particularly in regard to resistance against tumor growth.
Journal ArticleDOI
Natural Killer Cells: Characteristics and Regulation of Activity
Ronald B. Herberman,Ronald B. Herberman,Ronald B. Herberman,Julie Y. Djeu,Julie Y. Djeu,Julie Y. Djeu,H. David Kay,H. David Kay,H. David Kay,John R. Ortaldo,John R. Ortaldo,John R. Ortaldo,Carlo Riccardi,Carlo Riccardi,Carlo Riccardi,Guy D. Bonnard,Guy D. Bonnard,Guy D. Bonnard,Howard T. Holden,Howard T. Holden,Howard T. Holden,Roberto Fagnani,Roberto Fagnani,Roberto Fagnani,Angela Santoni,Paolo Puccetti,Paolo Puccetti,Paolo Puccetti +27 more
TL;DR: The views on the characteristics of NK cells are summarized and a few issues of current interest in the laboratory are focused on.
Journal ArticleDOI
Lead suppression of mouse resistance to Salmonella typhimurium
TL;DR: Lead-treated mice showed greater susceptibility to challenge with Salmonella typhimurium than controls which received no lead, confirming the hypothesis that treatment with lead reduces the resistance of mice to bacterial infection.
Journal ArticleDOI
Effect of Lead Acetate on the Susceptibility of Rats to Bacterial Endotoxins
H. Selye,B. Tuchweber,L. Bertok +2 more
TL;DR: Although lead acetate induces a high degree of susceptibility to various endotoxins, other reticuloendothelial blocking agents did not acquire unusual toxicity after pretreatment with lead, and none of the other metals or reticulum blocking agents tested could duplicate the pronounced decrease in endotoxin resistance induced by lead acetates.
Related Papers (5)
Lead suppression of mouse resistance to Salmonella typhimurium
Effect of chronic developmental lead exposure on cell-mediated immune functions.
R E Faith,M I Luster,C A Kimmel +2 more