Effect of Zinc on Efficacy of Iron Supplementation in Improving Iron and Zinc Status in Women
Phuong H. Nguyen,Ruben Grajeda,Paul Melgar,Jessica Marcinkevage,Rafael Flores,Usha Ramakrishnan,Reynaldo Martorell +6 more
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TLDR
Adding zinc to IFA supplements did not modify efficacy on iron status or improve zinc status, but daily supplementation was more efficacious than weekly in improving iron stores.Abstract:
Iron and zinc may interact in micronutrient supplements and thereby decrease efficacy. We investigated interactive effects of combined zinc and iron supplementation in a randomized controlled trial conducted in 459 Guatemalan women. Four groups were supplemented for 12 weeks: (1) weekly iron and folic acid (IFA); (2) weekly IFA and 30 mg zinc; (3) daily IFA; (4) daily IFA and 15 mg zinc. Effects were assessed by generalized linear regression. Baseline hemoglobin (Hb) concentration was 137.4 ± 15.5 g/L, 13% were anemic and 54% had zinc deficiency. Hb cconcentrations were similar by supplement type, but Hb concentrations improved significantly in anemic women at baseline (increase of 21.8 g/L). Mean percentage changes in serum ferritin were significantly higher in daily compared to weekly supplemented groups (86% versus 32%). The addition of zinc to IFA supplements had no significant impact on iron or zinc status. In conclusion, adding zinc to IFA supplements did not modify efficacy on iron status or improve zinc status, but daily supplementation was more efficacious than weekly in improving iron stores.read more
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References
More filters
Journal ArticleDOI
Longitudinal data analysis using generalized linear models
Kung Yee Liang,Scott L. Zeger +1 more
TL;DR: In this article, an extension of generalized linear models to the analysis of longitudinal data is proposed, which gives consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence.
Journal ArticleDOI
Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005
TL;DR: Anaemia affects one-quarter of the world’s population and is concentrated in preschool-aged children and women, making it a global public health problem, which makes it difficult to effectively address the problem.
Journal ArticleDOI
The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility
I.M.W. Ebisch,Chris M.G. Thomas,Wilbert H.M. Peters,Didi D.M. Braat,Régine P.M. Steegers-Theunissen +4 more
TL;DR: In this article, the role of nutritional and biochemical factors in reproduction and sub-fertility is discussed and a literature search is performed using MEDLINE, Science Direct and bibliographies of published work with both positive and negative results.
Journal ArticleDOI
Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal: double blind randomised community trial
Parul Christian,Subarna K. Khatry,Joanne Katz,Elizabeth K. Pradhan,Steven C. LeClerq,Sharada Ram Shrestha,Ramesh K. Adhikari,Alfred Sommer,Keith P. West +8 more
TL;DR: Antenatal folic acid-iron supplements modestly reduce the risk of low birth weight and multiple micronutrients confer no additional benefit over folic Acid-iron in reducing this risk.
Journal ArticleDOI
Micronutrient interactions: effects on absorption and bioavailability.
TL;DR: awareness of interactions between micronutrients affecting absorption and bioavailability, combined with a balanced evaluation of the dietary intake of the population with regard to absorption promoting and inhibiting substances and the risk for multiple deficiencies, could lead to more effective strategies to improvemicronutrient status in a population.