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Effects of stress throughout the lifespan on the brain, behaviour and cognition
Fernand Seguin,Hôpital Louis-H +1 more
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A model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives.Abstract:
Sonia J. Lupien*, Bruce S. McEwen ‡ , Megan R. Gunnar § and Christine Heim || Abstract | Chronic exposure to stress hormones, whether it occurs during the prenatal period, infancy, childhood, adolescence, adulthood or aging, has an impact on brain structures involved in cognition and mental health. However, the specific effects on the brain, behaviour and cognition emerge as a function of the timing and the duration of the exposure, and some also depend on the interaction between gene effects and previous exposure to environmental adversity. Advances in animal and human studies have made it possible to synthesize these findings, and in this Review a model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives.read more
Citations
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References
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Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Journal ArticleDOI
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Patrick O. McGowan,Aya Sasaki,Aya Sasaki,Ana C. D'Alessio,Sergiy Dymov,Benoit Labonté,Moshe Szyf,Gustavo Turecki,Michael J. Meaney,Michael J. Meaney +9 more
TL;DR: Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
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Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Dong Liu,Josie Diorio,Josie Diorio,Beth Tannenbaum,Beth Tannenbaum,Christian Caldji,Christian Caldji,Darlene D. Francis,Darlene D. Francis,Alison Freedman,Alison Freedman,Shakti Sharma,Shakti Sharma,Deborah Pearson,Deborah Pearson,Paul M. Plotsky,Paul M. Plotsky,Michael J. Meaney,Michael J. Meaney +18 more
TL;DR: It is suggested that maternal behavior serves to "program" hypothalamic-pituitary-adrenal responses to stress in the offspring.
Journal ArticleDOI
Why do many psychiatric disorders emerge during adolescence
TL;DR: The peak age of onset for many psychiatric disorders is adolescence, a time of remarkable physical and behavioural changes and answers to these questions might enable the understanding of mental health during adolescence.
Journal ArticleDOI
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*
TL;DR: The goal in the study of aging is not to halt the aging process, because we can no more be cured of aging than of birth as mentioned in this paper, but to slow and soften the sharpest edges of the biological unraveling that constitutes aging.