Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
John J. Aponte,David Schellenberg,Andrea Egan,Alasdair Breckenridge,Ilona Carneiro,Julia A Critchley,Ina Danquah,Alexander N. O. Dodoo,Robin Kobbe,Bertrand Lell,Bertrand Lell,Jürgen May,Zul Premji,Sergi Sanz,Esperanza Sevene,Rachida Soulaymani-Becheikh,Peter Winstanley,Samuel Adjei,Sylvester D. Anemana,Daniel Chandramohan,Saadou Issifou,Saadou Issifou,Frank P. Mockenhaupt,Seth Owusu-Agyei,Brian Greenwood,Martin P. Grobusch,Martin P. Grobusch,Peter G. Kremsner,Peter G. Kremsner,Eusebio Macete,Hassan Mshinda,Robert D. Newman,Laurence Slutsker,Marcel Tanner,Pedro L. Alonso,Clara Menéndez +35 more
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TLDR
IPTi with sulfadoxine-pyrimethamine was safe and efficacious across a range of malaria transmission settings, suggesting that this intervention is a useful contribution to malaria control.About:
This article is published in The Lancet.The article was published on 2009-10-31 and is currently open access. It has received 216 citations till now. The article focuses on the topics: Sulfadoxine & Sulfadoxine/pyrimethamine.read more
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World malaria report 2011
TL;DR: The World Health Organization (WHO) World Malaria Report 2021 estimates that there were 241 million malaria cases, including 627,000 deaths, worldwide in 2020, which represents around 14 million more cases, and 69,000 more deaths, than 2019.
World Malaria Report 2013
Kathryn G. Andrews,Cristin A Fergus,Maru Aregawi Epidemiologist,Richard E Cibulskis,Ghasem Zamani +4 more
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Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination
Teun Bousema,Chris Drakeley +1 more
TL;DR: How control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed are drawn together to show how the application of molecular techniques has led to the identification of submicroscopic gametocyte carriage and to a reassessment of the human infectious reservoir.
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New medicines to improve control and contribute to the eradication of malaria
TL;DR: Recent advances in genome-based technologies and in in vitro screening of whole parasites have broadened the range of therapeutic targets and are accelerating the development of a new generation of treatments for both malaria control and eradication.
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Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study
Meta Roestenberg,Anne C. Teirlinck,Matthew B. B. McCall,Karina Teelen,Krystelle Nganou Makamdop,Jorien Wiersma,Theo Arens,Pieter Beckers,Geert-Jan van Gemert,Marga van de Vegte-Bolmer,André J. A. M. van der Ven,Adrian J. F. Luty,Cornelus C. Hermsen,Robert W. Sauerwein +13 more
TL;DR: Artificially induced immunity lasts longer than generally recorded after natural exposure; providing a new avenue of research into the mechanisms of malaria immunity.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
A Modified Poisson Regression Approach to Prospective Studies with Binary Data
TL;DR: Results from a limited simulation study indicate that this approach is very reliable even with total sample sizes as small as 100, and the method is illustrated with two data sets.
Journal ArticleDOI
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants
Clara Menendez,Elizeus Kahigwa,R. Hirt,Penelope Vounatsou,John J. Aponte,F. Font,Camilo J. Acosta,David Schellenberg,Claudia M. Galindo,J. Kimario,Honorathy Urassa,Bernard J. Brabin,Thomas J. Smith,Andrew Y Kitua,Marcel Tanner,Pedro L. Alonso +15 more
TL;DR: Iron supplementation of infants to prevent iron-deficiency anaemia, even in malaria-endemic areas is supported, and malaria chemoprophylaxis during the first year of life was effective in prevention of malaria and anaemia but apparently impaired the development of natural immunity.
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Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised, placebo-controlled trial.
David Schellenberg,Clara Menendez,Elizeus Kahigwa,John J. Aponte,Josep Vidal,Marcel Tanner,Hassan Mshinda,Pedro L. Alonso +7 more
TL;DR: Intermittent sulphadoxine-pyrimethamine treatment was well tolerated and no drug-attributable adverse events were recorded and Serological responses to EPI vaccines were not affected by the intervention.
A strategic framework for malaria prevention and control during pregnancy in the African region
TL;DR: This document summarizes the aims and objectives of the WHO document, as well as investigating its applicability and scope and purpose, and some of the aspects of its development and usage.