Elementary and global aspects of calcium signalling.
TLDR
Using Ca2+ imaging techniques, the opening of individual channels has now been visualized and models have been proposed to explain how these elementary events are coordinated to generate the global Ca 2+ signals that regulate cellular activity.Abstract:
Calcium is a ubiquitous second messenger used to regulate a wide range of cellular processes. This role in signalling has to be conducted against the rigid homeostatic mechanisms that ensure that the resting level of Ca2+ is kept low (i.e. between 20 and 100 nmol l-1) in order to avoid the cytotoxic effects of a prolonged elevation of [Ca2+]. Cells have evolved a sophisticated signalling system based on the generation of brief pulses of Ca2+ which enables this ion to be used as a messenger, thus avoiding its toxic effects. Such Ca2+ spikes usually result from the coordinated release of Ca2+ from internal stores using either inositol 1,4,5-trisphosphate or ryanodine receptors. Using Ca2+ imaging techniques, the opening of individual channels has now been visualized and models have been proposed to explain how these elementary events are coordinated to generate the global Ca2+ signals that regulate cellular activity.read more
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References
More filters
Journal ArticleDOI
Gradation of Ca(2+)-induced Ca2+ release by voltage-clamp pulse duration in potentiated guinea-pig ventricular myocytes.
G Isenberg,Song Han +1 more
TL;DR: Testing the hypothesis that whole‐cell cardiac SR Ca2+ release is graded by recruitment of independent ‘release units’ suggests that the first opening of L‐type Ca2- channels determines whether the corresponding release unit contributes to the [Ca2+]c transient activated during a short voltage‐clamp pulse.
Journal ArticleDOI
Periodic calcium waves cross ascidian eggs after fertilization
TL;DR: It is found that the first few pulses start in the animal hemisphere, whereas the later ones are mostly initiated near the vegetal pole, and their possible role in establishing pattern or completing meiosis is discussed.
Journal ArticleDOI
Efficacy of peak Ca2+ currents (ICa) as trigger of sarcoplasmic reticulum Ca2+ release in myocytes from the guinea‐pig coronary artery.
Ganitkevich VYa,G Isenberg +1 more
TL;DR: The results suggest that a peak ICa can trigger a synchronized whole‐cell Ca2+ release only if ICa is strongly augmented.
Journal ArticleDOI
Dihydropyridine receptor-ryanodine receptor interactions in skeletal muscle excitation-contraction coupling.
Gerhard Meissner,Xiangyang Lu +1 more
TL;DR: Experiments with mutant muscle cells have indicated that skeletal muscle specific DHPR and RyR isoforms are required for skeletal muscle E-C coupling.
Journal ArticleDOI
Cyclic ADP-ribose: a new member of a super family of signalling cyclic nucleotides.
TL;DR: A new member of this family, cyclic ADP-ribose, is involved, instead, in mediating mobilization of Ca+2 from internal stores, and the signalling functions of the cyclic nucleotide family are now extended from protein phosphorylation to Ca-2 signalling.