Elementary and global aspects of calcium signalling.
TLDR
Using Ca2+ imaging techniques, the opening of individual channels has now been visualized and models have been proposed to explain how these elementary events are coordinated to generate the global Ca 2+ signals that regulate cellular activity.Abstract:
Calcium is a ubiquitous second messenger used to regulate a wide range of cellular processes. This role in signalling has to be conducted against the rigid homeostatic mechanisms that ensure that the resting level of Ca2+ is kept low (i.e. between 20 and 100 nmol l-1) in order to avoid the cytotoxic effects of a prolonged elevation of [Ca2+]. Cells have evolved a sophisticated signalling system based on the generation of brief pulses of Ca2+ which enables this ion to be used as a messenger, thus avoiding its toxic effects. Such Ca2+ spikes usually result from the coordinated release of Ca2+ from internal stores using either inositol 1,4,5-trisphosphate or ryanodine receptors. Using Ca2+ imaging techniques, the opening of individual channels has now been visualized and models have been proposed to explain how these elementary events are coordinated to generate the global Ca2+ signals that regulate cellular activity.read more
Citations
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Journal ArticleDOI
Effect of the antidepressant maprotiline on calcium movement and the viability of renal tubular cells
Shu-Shong Hsu,Wei-Chung Chen,Bang-Ping Jiann,Jin-Shyr Chen,Jong-Khing Huang,Hong-Tai Chang,He-Hsiung Cheng,Yuk-Keung Lo,Chin-Man Ho,Chung-Ren Jan +9 more
TL;DR: It is suggested that maprotiline rapidly increases [Ca2+]i in renal tubular cells by stimulating both extracellular Ca2+ influx and intracellular Ca 2+ release, and may modulate cell proliferation in a concentration-dependent manner.
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Ca2+ Mobilization Evoked by Chloroform in Madin-Darby Canine Kidney Cells
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Clomiphene, an Ovulation-Inducing Agent, Mobilizes Intracellular Ca2+ and Causes Extracellular Ca2+ Influx in Bladder Female Transitional Carcinoma Cells
TL;DR: The results suggest that clomiphene releases intracellular Ca2+ in an IP3-independent manner and also activates extracellular Ca 2+. influx.
Book ChapterDOI
Intercellular Calcium Signaling in “Non-Excitable” Cells
TL;DR: Embryogenesis, tissue ontogeny, cell growth and regeneration and the coordination of many tissue and cell functions could not occur in the absence of direct or indirect communication between cells.
Dissertation
Molecular characterization of novel ADP-ribosyl cyclases from the sea urchin
TL;DR: New insights are provided into the molecular mechanisms of multifunctionality of this remarkable family of enzymes and suggest that the expression and activities of ARCs could be fine-tuned for production of specific calcium messengers during embryogenesis of S.purpuratus.
References
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Journal ArticleDOI
Inositol trisphosphate and calcium signalling
TL;DR: Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle.
Journal ArticleDOI
Inositol trisphosphate, a novel second messenger in cellular signal transduction.
TL;DR: Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.
Journal ArticleDOI
A model for receptor-regulated calcium entry
TL;DR: A capacitative model is proposed for the mechanism by which activation of surface membrane receptors causes sustained Ca2+ entry into cells from the extracellular space, which allows forCa2+ release and Ca2-mobilization to be controlled by a single messenger, inositol (1,4,5) trisphosphate.
Journal ArticleDOI
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.
TL;DR: It is reported here that micromolar concentrations of Ins1,4,5P3 release Ca2+ from a nonmitochondrial intracellular Ca2- store in pancreatic acinar cells, and the results strongly suggest that this is the same Ca1+ store that is released by acetylcholine.
Journal ArticleDOI
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle
TL;DR: The calcium spark is the consequence of elementary events underlying excitation-contraction coupling and provides an explanation for both spontaneous and triggered changes in the intracellular calcium concentration in the mammalian heart.