Elementary and global aspects of calcium signalling.
TLDR
Using Ca2+ imaging techniques, the opening of individual channels has now been visualized and models have been proposed to explain how these elementary events are coordinated to generate the global Ca 2+ signals that regulate cellular activity.Abstract:
Calcium is a ubiquitous second messenger used to regulate a wide range of cellular processes. This role in signalling has to be conducted against the rigid homeostatic mechanisms that ensure that the resting level of Ca2+ is kept low (i.e. between 20 and 100 nmol l-1) in order to avoid the cytotoxic effects of a prolonged elevation of [Ca2+]. Cells have evolved a sophisticated signalling system based on the generation of brief pulses of Ca2+ which enables this ion to be used as a messenger, thus avoiding its toxic effects. Such Ca2+ spikes usually result from the coordinated release of Ca2+ from internal stores using either inositol 1,4,5-trisphosphate or ryanodine receptors. Using Ca2+ imaging techniques, the opening of individual channels has now been visualized and models have been proposed to explain how these elementary events are coordinated to generate the global Ca2+ signals that regulate cellular activity.read more
Citations
More filters
Journal ArticleDOI
The versatility and universality of calcium signalling
TL;DR: The universality of calcium as an intracellular messenger depends on its enormous versatility, which is exploited to control processes as diverse as fertilization, proliferation, development, learning and memory, contraction and secretion.
Journal ArticleDOI
Neuronal calcium signaling
TL;DR: This work was supported by a grant from the European Commission BIOMED2 (BMH4-CT96-0656) and has been endorsed by the Food and Drug Administration (FDA) for use in clinical practice.
Journal ArticleDOI
Inositol Trisphosphate Receptor Ca2+ Release Channels
TL;DR: Over the last decade, detailed quantitative studies of InsP3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation.
Journal ArticleDOI
The endoplasmic reticulum: a multifunctional signaling organelle
TL;DR: The endoplasmic reticulum is a multifunctional signaling organelle that controls a wide range of cellular processes such as the entry and release of Ca(2+), sterol biosynthesis, apoptosis and the release of arachidonic acid.
Journal ArticleDOI
Influence of the Testa on Seed Dormancy, Germination, and Longevity in Arabidopsis
TL;DR: Both structural and pigmentation mutants deteriorated faster than the wild types during natural aging at room temperature, with structural mutants being the most strongly affected.
References
More filters
Journal ArticleDOI
The regulation of capacitative calcium entry by calcium and protein kinase C in Xenopus oocytes.
TL;DR: A variety of protocols revealed highly nonlinear behavior of the calcium entry in thapsigargin-treated oocytes suggestive of positive and negative feedback by calcium at the level of its own entry.
Journal ArticleDOI
Luminal Ca2+ promoting spontaneous Ca2+ release from inositol trisphosphate-sensitive stores in rat hepatocytes.
TL;DR: The results suggesting that luminal Ca2+ may sensitive InsP3‐sensitive stores leading to spontaneous Ca2+.
Journal ArticleDOI
Ca2+ transients associated with openings of inositol trisphosphate‐gated channels in Xenopus oocytes.
Ian Parker,Yong Yao +1 more
TL;DR: It is concluded that blips may arise through opening of single InsP3‐gated channels, whereas puffs reflect the concerted opening of several clustered channels due to local regenerative feedback by Ca2+.
Journal ArticleDOI
Properties of calcium stores and transient outward currents in single smooth muscle cells of rabbit intestine.
Thomas B. Bolton,S P Lim +1 more
TL;DR: The results suggest that the effect of guanine nucleotide analogues are on the calcium store rather than on calcium‐activated potassium channels, as well as a direct effect on stores.
Journal ArticleDOI
Contribution of Ca(2+)-induced Ca2+ release to the [Ca2+]i transients in myocytes from guinea-pig urinary bladder.
V Y Ganitkevich,G Isenberg +1 more
TL;DR: It is concluded that depolarization‐induced influx of Ca2+ through L‐type Ca2- channels induces the release of Ca 2+ from intracellular caffeine‐sensitive stores which constitutes the major part of the phasic component.