Journal ArticleDOI
Emotional tagging of memory formation--in the search for neural mechanisms.
Gal Richter-Levin,Irit Akirav +1 more
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TLDR
Evidence is reviewed from both human and animal studies that lend support to the Emotional Tagging hypothesis and to the central role the amygdala may play in its formation and on potential neural mechanisms that may underlie emotional tagging.About:
This article is published in Brain Research Reviews.The article was published on 2003-12-01. It has received 171 citations till now. The article focuses on the topics: Metaplasticity & Synaptic plasticity.read more
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Synaptic AMPA Receptor Plasticity and Behavior
TL;DR: It is argued that monitoring and manipulating synaptic AMPAR trafficking represents an attractive means to study cognitive function and dysfunction in animal models.
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The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law
TL;DR: It is proposed that with the onset of strong emotionality, the hippocampus rapidly shifts from a “configural/cognitive map” mode to a ‘flashbulb memory’ mode, which underlies the long-lasting, but fragmented, nature of traumatic memories.
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Stress and memory: behavioral effects and neurobiological mechanisms.
TL;DR: High stress levels, whether intrinsic or extrinsic, tend to facilitate Pavlovian conditioning (in a linear-asymptotic manner), while being deleterious for spatial/explicit information processing (which with regard to intrinsic stress levels follows an inverted U-shape effect).
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The influence of stress hormones on fear circuitry
TL;DR: This work discusses how stress and the endocrine mediators of the stress response influence the morphological and electrophysiological properties of neurons in brain areas that are crucial for fear-conditioning processes, including the amygdala, hippocampus, and prefrontal cortex.
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Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking
Hailan Hu,Eleonore Real,Kogo Takamiya,Myoung-Goo Kang,Joseph E. LeDoux,Richard L. Huganir,Roberto Malinow +6 more
TL;DR: Examination of the role of NE in contextual memory formation and in the synaptic delivery of GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors during long-term potentiation (LTP), a candidate synaptic mechanism for learning, indicates that NE-driven phosphorylation of GLUR1 facilitates the synaptic deliveries of Glamorganically-containing AMPARs.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
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Emotion Circuits in the Brain
TL;DR: The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area, and much of the progress has come from studies of fear, and especially fear conditioning as mentioned in this paper.
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Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
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Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
TL;DR: The role of the hippocampus is considered, which is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory.