Endophytic Fungi-Alternative Sources of Cytotoxic Compounds: A Review.
Fazilath Uzma,Chakrabhavi Dhananjaya Mohan,Abeer Hashem,Narasimha Murthy Konappa,Shobith Rangappa,Praveen Vadakke Kamath,Bhim Singh,Venkataramana Mudili,Vijai Kumar Gupta,Chandra Nayaka Siddaiah,Srinivas Chowdappa,Abdulaziz A. Alqarawi,Elsayed Fathi Abd_Allah +12 more
TLDR
This review offers a current and integrative account of clinically used anticancer drugs such as taxol, podophyllotoxin, camptothecin, and vinca alkaloids in terms of their mechanism of action, isolation from endophytic fungi and their characterization, yield obtained, and fungal strain improvement strategies.Abstract:
Cancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global challenge to explore newer sources of anticancer drugs. Recent advancements in cancer treatment involve the discovery and development of new and improved chemotherapeutics derived from natural or synthetic sources. Natural sources offer the potential of finding new structural classes with unique bioactivities for cancer therapy. Endophytic fungi represent a rich source of bioactive metabolites that can be manipulated to produce desirable novel analogs for chemotherapy. This review offers a current and integrative account of clinically used anticancer drugs such as taxol, podophyllotoxin, camptothecin, and vinca alkaloids in terms of their mechanism of action, isolation from endophytic fungi and their characterization, yield obtained, and fungal strain improvement strategies. It also covers recent literature on endophytic fungal metabolites from terrestrial, mangrove, and marine sources as potential anticancer agents and emphasizes the findings for cytotoxic bioactive compounds tested against specific cancer cell lines.read more
Citations
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Journal ArticleDOI
Biological Control of Plant-Parasitic Nematodes by Filamentous Fungi Inducers of Resistance: Trichoderma, Mycorrhizal and Endophytic Fungi.
Jorge Poveda,Jorge Poveda,Patricia Abril-Urias,Patricia Abril-Urias,Carolina Escobar,Carolina Escobar +5 more
TL;DR: The use of filamentous fungi as biological control agents against plant-parasitic nematodes has been studied in this paper, where the authors showed that the use of mycorrhizal and endophytic fungi as resistance inducers is a promising durable biocontrol strategy in agriculture.
Journal ArticleDOI
A critical review on exploiting the pharmaceutical potential of plant endophytic fungi.
TL;DR: How advanced chemical, biotechnological and computational molecular biology methods can be used for robust exploitation of bioactive compounds from these microorganisms is focused on.
Book ChapterDOI
Biodiversity of Endophytic Fungi from Diverse Niches and Their Biotechnological Applications
Kusam Lata Rana,Divjot Kour,Imran Sheikh,Neelam Yadav,Ajar Nath Yadav,Vinod Kumar,Bhim Singh,Harcharan Singh Dhaliwal,Anil Kumar Saxena +8 more
TL;DR: This chapter presents a critical review of the isolation, characterization, identification, biodiversity, and potential applications of endophytic fungi in agriculture and allied sectors.
Journal ArticleDOI
Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature
Chakrabhavi Dhananjaya Mohan,Shobith Rangappa,Habbanakuppe D. Preetham,S. Chandra Nayaka,Vijai Kumar Gupta,Salundi Basappa,Gautam Sethi,Kanchugarakoppal S. Rangappa +7 more
TL;DR: This review has provided a comprehensive overview of mechanisms of STAT3 signal transduction and its endogenous negative modulators, the role ofSTAT3 in oncogenesis, the interplay of miRNAs in STAT3 signaling, and mechanisms involved in persistent activation of stat3.
Journal ArticleDOI
Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds
Chakrabhavi Dhananjaya Mohan,Swetha Hari,Habbanakuppe D. Preetham,Shobith Rangappa,Uri Barash,Neta Ilan,S. Chandra Nayak,Vijai Kumar Gupta,Basappa,Israel Vlodavsky,Kanchugarakoppal S. Rangappa +10 more
TL;DR: The key roles of heparanase in cancer progression are discussed focusing on the status of natural, chemically modified, and synthetic heParanase inhibitors in various types of malignancies.
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Topoisomerase I inhibitors : camptothecins and beyond
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