Endostatin associates with lipid rafts and induces reorganization of the actin cytoskeleton via down-regulation of RhoA activity.
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TLDR
Observations that endostatin inhibits endothelial cell migration and induces disassembly of the actin cytoskeleton provide putative cellular mechanisms for this effect, which plausibly explains the anti-angiogenic mechanisms ofendostatin in vivo.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-09-26 and is currently open access. It has received 139 citations till now. The article focuses on the topics: Endostatin & Actin cytoskeleton.read more
Citations
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Basement membrane proteoglycans: from cellar to ceiling.
TL;DR: New findings indicate a potential functional coupling between the intricate make-up of basement membrane proteoglycans and their ability to control important biological processes.
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Pericellular Proteases in Angiogenesis and Vasculogenesis
TL;DR: Understanding the complexity of protease activities in angiogenesis contributes to recognizing new targets for stimulation or inhibition of neovascularization in disease.
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Characterization of Lipid Rafts from Medicago truncatula Root Plasma Membranes: A Proteomic Study Reveals the Presence of a Raft-Associated Redox System
Benoit Lefebvre,Fabienne Furt,Marie-Andrée Hartmann,Louise V. Michaelson,Jean-Pierre Carde,Françoise Sargueil-Boiron,Michel Rossignol,Johnathan A. Napier,Julie V. Cullimore,Jean-Jacques Bessoule,Sébastien Mongrand +10 more
TL;DR: It is shown that lipid raft domains, defined as Triton X-100-insoluble membranes, can also be prepared from Medicago truncatula root PMs, and that receptor kinases and proteins related to signaling, cellular trafficking, and cell wall functioning were well represented whereas those involved in transport and metabolism were poorly represented.
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Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin
Gregory J. Bix,Jian Fu,E González,Laura Macro,Amy Barker,Shelly Campbell,Mary M. Zutter,Samuel A. Santoro,Jiyeun Kate Kim,Magnus Höök,Charles C. Reed,Renato V. Iozzo +11 more
TL;DR: Evidence is provided for a novel biological axis that links a soluble fragment of perlecan protein core to the major cell surface receptor for collagen I, alpha2beta1 integrin, and an initial investigation of the intracellular signaling events that lead to endorepellin antiangiogenic activity.
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Lipid Raft Clustering and Redox Signaling Platform Formation in Coronary Arterial Endothelial Cells
TL;DR: The results suggest that LR clustering occurs in coronary endothelial cells, and the formation of redox signaling platforms on the cell membrane mediates transmembrane signaling of death receptors, resulting in endothelial dysfunction.
References
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Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
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Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
TL;DR: The work from the authors' laboratories reviewed herein was supported by grants from the National Cancer Institute.
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Lipid rafts and signal transduction
Kai Simons,Derek Toomre +1 more
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.
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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
Michael S. O'Reilly,Thomas Boehm,Yuen Shing,Naomi Fukai,George Vasios,William S. Lane,Evelyn Flynn,James R Birkhead,Bjorn R. Olsen,Judah Folkman +9 more
TL;DR: This work has identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma, a 20 kDa C-terminal fragment of collagen XVIII that specifically inhibits endothelial proliferation and potently inhibitsAngiogenesis and tumor growth.
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Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.