Engineered bacteria to report gut function: technologies and implementation.
TLDR
Recent engineering approaches applied in vivo in animal models are summarized and promising technologies for designing the next generation of bacterial biosensors are highlighted.About:
This article is published in Current Opinion in Microbiology.The article was published on 2021-02-01 and is currently open access. It has received 20 citations till now.read more
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Stimuli-responsive engineered living materials
TL;DR: The emerging area of engineered living materials (ELMs) includes composites that combine living cells and synthetic materials as mentioned in this paper, which are able to undergo controllable changes in materials properties in response to external cues.
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Synthetic DNA applications in information technology
Linda C. Meiser,Bichlien H. Nguyen,Yuan-Jyue Chen,Jeffrey M. Nivala,Karin Strauss,Luis Ceze,Robert N. Grass +6 more
TL;DR: In this paper , the authors provide an overview of the most prevalent applications of synthetic DNA that could shape the future of information technology and emphasize the reasons why the biomolecule can be a valuable alternative for conventional electronic-based media, and give insights on where DNA-analog technology stands with respect to its electronic counterparts.
Journal ArticleDOI
Synthetic DNA applications in information technology
Linda C. Meiser,Bichlien H. Nguyen,Yuan-Jyue Chen,Jeffrey M. Nivala,Karin Strauss,Luis Ceze,Robert N. Grass +6 more
TL;DR: In this article , the authors provide an overview of the most prevalent applications of synthetic DNA that could shape the future of information technology and emphasize the reasons why the biomolecule can be a valuable alternative for conventional electronic-based media, and give insights on where DNA-analog technology stands with respect to its electronic counterparts.
Journal ArticleDOI
Prokaryotic reverse transcriptases: from retroelements to specialized defense systems
TL;DR: Prokaryotic reverse transcriptases (RTs) catalyze the polymerization of DNA from an RNA template as discussed by the authors, and are key components of different lines of defense against phages and other mobile genetic elements.
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Recent advances in the analytical strategies of microbial biosensor for detection of pollutants.
Zengling Ma,Catarina Meliana,Heli Siti Halimatul Munawaroh,Ceren Karaman,Hassan Karimi-Maleh,Sze Shin Low,Pau Loke Show +6 more
TL;DR: In this paper , a review summarizes all the current applications of bacterial-, microalgal-, fungal-, and viral-based biosensors in regard to environmental, food, and medical-related applications.
References
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The Human Intestinal Microbiome in Health and Disease
Susan V. Lynch,Oluf Pedersen +1 more
TL;DR: The large majority of studies on the role of the microbiome in the pathogenesis of disease are correlative and preclinical; several have influenced clinical practice.
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Current understanding of the human microbiome.
Jack A. Gilbert,Jack A. Gilbert,Jack A. Gilbert,Martin J. Blaser,J. Gregory Caporaso,Janet K. Jansson,Susan V. Lynch,Rob Knight +7 more
TL;DR: This review focuses on studies in humans to describe challenges and propose strategies that leverage existing knowledge to move rapidly from correlation to causation and ultimately to translation into therapies.
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Synthesis of clathrate cerium superhydride CeH9 at 80-100 GPa with atomic hydrogen sublattice.
Nilesh P. Salke,M. Mahdi Davari Esfahani,Youjun Zhang,Ivan A. Kruglov,Jianshi Zhou,Yaguo Wang,Eran Greenberg,Vitali B. Prakapenka,Jin Liu,Artem R. Oganov,Artem R. Oganov,Artem R. Oganov,Jung-Fu Lin +12 more
TL;DR: It is shown that CeH9 can be synthesized at 80-100 GPa with laser heating, and is characterized by a clathrate structure with a dense 3-dimensional atomic hydrogen sublattice, which shed a significant light on the search for superhydrides in close similarity with atomic hydrogen within a feasible pressure range.
Journal ArticleDOI
Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Eran Kotler,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Yotam Cohen,Raquel Linevsky,Daphna Rothschild,Andreas E. Moor,Shani Ben-Moshe,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Hagit Shapiro,Meirav Pevsner-Fischer,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: The metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome, indicating that empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa.
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Laboratory markers in IBD: useful, magic, or unnecessary toys?
TL;DR: Until more data become available, the use of CRP and other laboratory markers should be seen as an additive tool to clinical observation and physical examination rather than a replacement.