Journal ArticleDOI
Enzymatic production and biological activities of chitosan oligosaccharides (COS): A review
Se-Kwon Kim,Niranjan Rajapakse +1 more
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This review has summarized different enzymatic preparation methods of COS and some of their reported biological activities, such as antimicrobial, anticancer, antioxidant, and immunostimulant effects are depend on their physico-chemical properties.About:
This article is published in Carbohydrate Polymers.The article was published on 2005-12-14. It has received 763 citations till now.read more
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Anti-photoaging effects of chitosan oligosaccharide in ultraviolet-irradiated hairless mouse skin
Songzhi Kong,Dong-Dong Li,Hui Luo,Wen-Jie Li,Yongmei Huang,Ji-Cheng Li,Zhang Hu,Na Huang,Min-Hui Guo,Yao Chen,Sidong Li +10 more
TL;DR: Investigation of the potential preventive effect of COS against UV‐caused damage in hairless mouse dorsal skin demonstrated that this natural polysaccharide attenuated UV‐induced SP, at least in part, by virtue of favorable regulation of antioxidant and anti‐inflammatory status.
Journal ArticleDOI
Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis
Neslihan Üstündağ-Okur,Evren Gökçe,Duygu İnci Bozbıyık,Sait Egrilmez,Gökhan Ertan,Özgen Özer +5 more
TL;DR: NLC-based inserts developed with the addition of glycerin (Ins3OFX) was found as optimal and may be offered as appropriate vehicles for ocular delivery.
Journal ArticleDOI
Gallic acid-grafted chitooligosaccharides suppress antigen-induced allergic reactions in RBL-2H3 mast cells.
TL;DR: The inhibitory activities of G-COS on allergic reactions were found as a consequence of suppression of FcεRI expression in antigen-stimulated cells, and it was suggested to be a promising candidate of novel inhibitors against allergic reactions.
Journal ArticleDOI
Influence of the physico-chemical characteristics of chito-oligosaccharides (COS) on antioxidant activity
TL;DR: A correlation was found between the relative amount of molecules with a given A/D ratio within the COS and their antioxidant activity, which could be used to predict the antioxidant behavior of a fraction of chito-oligosaccharides.
Journal ArticleDOI
Chitosan oligosaccharide-based dual pH responsive nano-micelles for targeted delivery of hydrophobic drugs.
Yulong Wang,Yulong Wang,Avik Khan,Yanxin Liu,Jing Feng,Lei Dai,Guanhua Wang,Nur Alam,Li Tong,Yonghao Ni +9 more
TL;DR: The overall concept of DPRNs for the targeted delivery of hydrophobic anticancer drugs was successfully demonstrated and the resultant genistein-loaded DPRNs were stable under the physiological pH and under the cancer cell extracellular pH.
References
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Journal ArticleDOI
Food applications of chitin and chitosans
TL;DR: Application of chitinous products in foods and pharmaceuticals as well as processing aids has received considerable attention in recent years as exotic synthetic compounds are losing their appeal.
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Antibacterial action of chitosan
TL;DR: Fungal chitosan had significantly less antibiotic effect than CH and CL, and was shown to be concentration dependent with 0.1 mg/mL more effective than 2.0 and 5.0 mg/ mL.
Journal ArticleDOI
Chitosan: A Unique Polysaccharide for Drug Delivery
TL;DR: The aim of this review is to give an insight into the many potential applications of chitosan as a pharmaceutical drug carrier.
BookDOI
Chitin in nature and technology
TL;DR: Chitin has been a landmark for polysaccharides and modified chitins, besides chitin itself, to the point that three International Conferences on Chitin / Chitosan were convened (Boston, U.S. A. 1977, Sapporo, Japan 1982 and Senigallia, Italy 1985).
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Antimicrobial effect of chitooligosaccharides produced by bioreactor
TL;DR: In this paper, the antibacterial effect of three kinds of chitooligosaccharides with relatively higher molecular weights (HMWCOS), medium molecular weight (MMWCOS), and lower molecular weight, respectively, was evaluated against various microorganisms.