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Enzyme catalysis in organic synthesis : a comprehensive handbook

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TLDR
A tabular survey of commercially available enzymes can be found in this paper, with a focus on enzymes that are used in organic synthesis, such as: production and isolation of enzymes, immobilization of enzymes reaction techniques, use of growing or resting cells, applications of enqumes in organically synthesized organic synthesis hydrolysis and formation of C-O bonds, C-N bonds, P-O bond formation, reduction reactions oxidation reactions isomerizations introduction and removal of protecting groups extremophiles catalytic antibodies enqumatic analysis and biosensors prtoein engineering
Abstract
Production and isolation of enzymes immobilization of enzymes reaction techniques use of growing or resting cells applications of enqumes in organic synthesis hydrolysis and formation of C-O bonds, C-N bonds, P-O bonds formation of C-C bonds reduction reactions oxidation reactions isomerizations introduction and removal of protecting groups extremophiles catalytic antibodies enqumatic analysis and biosensors prtoein engineering tabular survey of commercially available enzymes.

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The potential of enzymatic catalysis in supercritical fluids

TL;DR: In this chapter, the main features and possibilities of enzymatic catalysis in supercritical fluids are described and the most relevant parameters including the effect of the applied immobilization method, the influence of mass transfer, and the effects of pressure and water activity on the catalytic activity are discussed.
Journal ArticleDOI

Differential effect of a chemical denaturant on activity and stability of a serine protease in nonaqueous media

TL;DR: The use of an enzyme for commercial applications is dependent upon a compromise between activity and (operational) stability, as well as the mechanism behind this phenomenon has not been investigated in detail.
Journal ArticleDOI

First stereoselective acylation of a primary diol possessing a prochiral quaternary center mediated by lipase TL from Pseudomonas stutzeri

TL;DR: Optimal conditions were designed by testing different experimental conditions on model substrates to find best organic solvent, optimal acyl donor and temperature, as well as the optimal substrates/enzyme ratio to achieve lipase-catalyzed monoacylation.
Book ChapterDOI

Directed evolution of enantioselective enzymes as catalysts in the production of chiral pharmaceuticals

TL;DR: This chapter proposes a radically different approach to the development of enantioselective catalysts, which does not rely on any knowledge regarding the structure of the enzyme or on any speculations concerning enzyme mechanism.
Journal ArticleDOI

Selective production of 1-monocaprin by porcine liver carboxylesterase-catalyzed esterification: Its enzyme kinetics and catalytic performance.

TL;DR: The degree of esterification at equilibrium state (after 4 h from the initiation) was 62.7% under the optimum conditions at pH 7.0 and 60 °C and the PLE mainly produced 1-monocaprin without any other products (di- and/or tricaprins of subsequent reactions).