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Enzyme catalysis in organic synthesis : a comprehensive handbook
Karlheinz Drauz,Herbert Waldmann +1 more
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TLDR
A tabular survey of commercially available enzymes can be found in this paper, with a focus on enzymes that are used in organic synthesis, such as: production and isolation of enzymes, immobilization of enzymes reaction techniques, use of growing or resting cells, applications of enqumes in organically synthesized organic synthesis hydrolysis and formation of C-O bonds, C-N bonds, P-O bond formation, reduction reactions oxidation reactions isomerizations introduction and removal of protecting groups extremophiles catalytic antibodies enqumatic analysis and biosensors prtoein engineeringAbstract:
Production and isolation of enzymes immobilization of enzymes reaction techniques use of growing or resting cells applications of enqumes in organic synthesis hydrolysis and formation of C-O bonds, C-N bonds, P-O bonds formation of C-C bonds reduction reactions oxidation reactions isomerizations introduction and removal of protecting groups extremophiles catalytic antibodies enqumatic analysis and biosensors prtoein engineering tabular survey of commercially available enzymes.read more
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The potential of enzymatic catalysis in supercritical fluids
TL;DR: In this chapter, the main features and possibilities of enzymatic catalysis in supercritical fluids are described and the most relevant parameters including the effect of the applied immobilization method, the influence of mass transfer, and the effects of pressure and water activity on the catalytic activity are discussed.
Journal ArticleDOI
Differential effect of a chemical denaturant on activity and stability of a serine protease in nonaqueous media
TL;DR: The use of an enzyme for commercial applications is dependent upon a compromise between activity and (operational) stability, as well as the mechanism behind this phenomenon has not been investigated in detail.
Journal ArticleDOI
First stereoselective acylation of a primary diol possessing a prochiral quaternary center mediated by lipase TL from Pseudomonas stutzeri
A Pizzilli,R. Zoppi,Pilar Hoyos,S. Gómez,Francesco Gilberto Gatti,María J. Hernáiz,Andrés R. Alcántara +6 more
TL;DR: Optimal conditions were designed by testing different experimental conditions on model substrates to find best organic solvent, optimal acyl donor and temperature, as well as the optimal substrates/enzyme ratio to achieve lipase-catalyzed monoacylation.
Book ChapterDOI
Directed evolution of enantioselective enzymes as catalysts in the production of chiral pharmaceuticals
TL;DR: This chapter proposes a radically different approach to the development of enantioselective catalysts, which does not rely on any knowledge regarding the structure of the enzyme or on any speculations concerning enzyme mechanism.
Journal ArticleDOI
Selective production of 1-monocaprin by porcine liver carboxylesterase-catalyzed esterification: Its enzyme kinetics and catalytic performance.
Kyung-Min Park,Jong-Hyuk Lee,Sung Chul Hong,Chang Woo Kwon,Minje Jo,Seung Jun Choi,Keesung Kim,Pahn-Shick Chang +7 more
TL;DR: The degree of esterification at equilibrium state (after 4 h from the initiation) was 62.7% under the optimum conditions at pH 7.0 and 60 °C and the PLE mainly produced 1-monocaprin without any other products (di- and/or tricaprins of subsequent reactions).