Epidemiology and Control of Neosporosis and Neospora caninum
TLDR
This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated.Abstract:
Neospora caninum is a protozoan parasite of animals. Until 1988, it was misidentified as Toxoplasma gondii. Since its first recognition in dogs in 1984 and the description of the new genus and species Neospora caninum in 1988, neosporosis has emerged as a serious disease of cattle and dogs worldwide. Abortions and neonatal mortality are a major problem in livestock operations, and neosporosis is a major cause of abortion in cattle. Although antibodies to N. caninum have been reported, the parasite has not been detected in human tissues. Thus, the zoonotic potential is uncertain. This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated. The role of wildlife in the life cycle of N. caninum and strategies for the control of neosporosis in cattle are discussed.read more
Citations
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Journal ArticleDOI
Vaccines against neosporosis: what can we learn from the past studies?
Thierry Monney,Andrew Hemphill +1 more
TL;DR: The recent advances made in vaccine development against N. caninum in cattle and in mice are summarized and the most important factors are highlighted, which are likely to influence the degree of protection mediated by vaccination.
Journal ArticleDOI
In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum.
Pablo Winzer,Joachim Müller,Adriana Aguado-Martínez,Mahbubur Rahman,Vreni Balmer,Vera Manser,Luis Miguel Ortega-Mora,Kayode K. Ojo,Erkang Fan,Dustin J. Maly,Wesley C. Van Voorhis,Andrew Hemphill +11 more
TL;DR: In a pregnant mouse model, BKI-1294 efficiently inhibited vertical transmission in BALB/c mice experimentally infected with one of the two virulent isolates Nc-Liv or N c-Spain7, demonstrating proof of concept that this compound protected offspring from vertical transmission and disease.
Journal ArticleDOI
Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.
Kayode K. Ojo,Molly C. Reid,Latha Kallur Siddaramaiah,Joachim Müller,Pablo Winzer,Zhongsheng Zhang,Katelyn R. Keyloun,Rama Subba Rao Vidadala,Ethan A. Merritt,Wim G. J. Hol,Dustin J. Maly,Erkang Fan,Wesley C. Van Voorhis,Andrew Hemphill +13 more
TL;DR: Proof-of-concept for BKIs, and 1294 specifically, for therapy of bovine and canine neosporosis is demonstrated, to determine the PK, optimal dosage, and duration for effective treatment in cattle and dogs.
Journal ArticleDOI
Bovine neosporosis: Clinical and practical aspects
TL;DR: A set of recommendations is provided for veterinarians and cattle farmers based on the implications of clinical findings reported to date and on prospects for its control in cattle.
Journal ArticleDOI
Infected Dendritic Cells Facilitate Systemic Dissemination and Transplacental Passage of the Obligate Intracellular Parasite Neospora caninum in Mice
Esther Collantes-Fernández,Esther Collantes-Fernández,Esther Collantes-Fernández,Romanico B. G. Arrighi,Romanico B. G. Arrighi,Gema Álvarez-García,Jessica M. Weidner,Jessica M. Weidner,Javier Regidor-Cerrillo,John C. Boothroyd,Luis Miguel Ortega-Mora,Antonio Barragan,Antonio Barragan +12 more
TL;DR: It is described that infection of dendritic cells by N. caninum tachyzoites potentiated translocation of parasites across polarized cellular monolayers, indicative of conserved dissemination strategies among coccidian apicomplexan parasites.
References
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Journal ArticleDOI
Dogs are definitive hosts of Neospora caninum.
Milton M. McAllister,Jitender P. Dubey,David S. Lindsay,Jolley Wr,Rebecca A Wills,McGuire Am +5 more
TL;DR: Dogs are a definitive host of Neospora caninum, and mice inoculated with canine faecal extracts were monitored for evidence of neosporosis using a variety of morphologic, immunohistologic, serologic, and genetic analyses.
Journal ArticleDOI
A review of Neospora caninum and neosporosis
TL;DR: Neospora caninum is a recently recognized protozoan parasite of animals, which until 1988 was misidentified as Toxoplasma gondii, and its life cycle is unknown.
Journal Article
Newly recognized fatal protozoan disease of dogs
TL;DR: A newly identified parasite, Neospora caninum, structurally distinct from T gondii, was found in 10 dogs and formed meronts in many tissues of the dogs, especially the brain and spinal cord.
Journal ArticleDOI
Review of Neospora caninum and neosporosis in animals.
TL;DR: Information on biology, diagnosis, epidemiology and control of neosporosis in animals, a major cause of abortion in cattle in many countries, is reviewed.
Journal Article
Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission.
TL;DR: Neospora caninum infection was diagnosed in 5 young dogs from 2 litters with a common parentage that developed hind limb paresis 5 to 8 weeks after birth and was isolated in cell cultures, mice, and dogs inoculated with infected canine tissues.