Epidemiology and Control of Neosporosis and Neospora caninum
TLDR
This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated.Abstract:
Neospora caninum is a protozoan parasite of animals. Until 1988, it was misidentified as Toxoplasma gondii. Since its first recognition in dogs in 1984 and the description of the new genus and species Neospora caninum in 1988, neosporosis has emerged as a serious disease of cattle and dogs worldwide. Abortions and neonatal mortality are a major problem in livestock operations, and neosporosis is a major cause of abortion in cattle. Although antibodies to N. caninum have been reported, the parasite has not been detected in human tissues. Thus, the zoonotic potential is uncertain. This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated. The role of wildlife in the life cycle of N. caninum and strategies for the control of neosporosis in cattle are discussed.read more
Citations
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Journal ArticleDOI
Molecular comparison of Neospora caninum oocyst isolates from naturally infected dogs with cell culture-derived tachyzoites of the same isolates using nested polymerase chain reaction to amplify microsatellite markers
W. Basso,Susann Schares,Andrea Bärwald,Daland Herrmann,Franz Josef Conraths,Nikola Pantchev,M. Globokar Vrhovec,Gereon Schares +7 more
TL;DR: The aim of the present study was to analyse N. caninum oocysts from the faeces of naturally infected dogs using a microsatellite-based typing technique and to compare them with cell culture-derived tachyzoites of the same isolates.
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Prevalence of antibodies against Toxoplasma gondii and Neospora caninum in moose (Alces alces) and roe deer (Capreolus capreolus) in Sweden.
TL;DR: Investigation of the seroprevalences of T. gondii, and N. caninum in moose, and roe deer in Sweden shows that toxoplasmosis infection is widely spread, and precautions should be taken when handling internal organs and carcasses of harvested cervids.
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Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.
Wesley C. Van Voorhis,J. Stone Doggett,Marilyn Parsons,Marilyn Parsons,Matthew A. Hulverson,Ryan Choi,Samuel L.M. Arnold,Michael W. Riggs,Andrew Hemphill,Daniel K. Howe,Robert H. Mealey,Audrey O.T. Lau,Ethan A. Merritt,Dustin J. Maly,Erkang Fan,Kayode K. Ojo +15 more
TL;DR: Evaluation of efficacy against the kinase target, parasite growth in vitro, and in animal infection models, as well as the relevant pharmacokinetic and safety parameters of bumped kinase inhibitors are reviewed.
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Genetic Diversity and Geographic Population Structure of Bovine Neospora caninum Determined by Microsatellite Genotyping Analysis
Javier Regidor-Cerrillo,Francisco Díez-Fuertes,Alicia García-Culebras,Dadin Prando Moore,Marta González-Warleta,Carmen Cuevas,Gereon Schares,Frank Katzer,Susana Pedraza-Díaz,Mercedes Mezo,Luis Miguel Ortega-Mora +10 more
TL;DR: The presence of linkage disequilibrium, the co-existence of specific MLGs to individual farms and eBURST MLG relationships suggest a predominant clonal propagation for Spanish N .
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Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites
TL;DR: Quantification of viable tachyzoites in brain tissue of intra-nasally vaccinated mice showed that immunization with recNcPDI resulted in significantly decreased numbers of live parasites, showing that, besides the nature of the antigen, the protective effect of vaccination also depends largely on the route of antigen delivery.
References
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Dogs are definitive hosts of Neospora caninum.
Milton M. McAllister,Jitender P. Dubey,David S. Lindsay,Jolley Wr,Rebecca A Wills,McGuire Am +5 more
TL;DR: Dogs are a definitive host of Neospora caninum, and mice inoculated with canine faecal extracts were monitored for evidence of neosporosis using a variety of morphologic, immunohistologic, serologic, and genetic analyses.
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A review of Neospora caninum and neosporosis
TL;DR: Neospora caninum is a recently recognized protozoan parasite of animals, which until 1988 was misidentified as Toxoplasma gondii, and its life cycle is unknown.
Journal Article
Newly recognized fatal protozoan disease of dogs
TL;DR: A newly identified parasite, Neospora caninum, structurally distinct from T gondii, was found in 10 dogs and formed meronts in many tissues of the dogs, especially the brain and spinal cord.
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Review of Neospora caninum and neosporosis in animals.
TL;DR: Information on biology, diagnosis, epidemiology and control of neosporosis in animals, a major cause of abortion in cattle in many countries, is reviewed.
Journal Article
Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission.
TL;DR: Neospora caninum infection was diagnosed in 5 young dogs from 2 litters with a common parentage that developed hind limb paresis 5 to 8 weeks after birth and was isolated in cell cultures, mice, and dogs inoculated with infected canine tissues.