Epidemiology and Control of Neosporosis and Neospora caninum
TLDR
This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated.Abstract:
Neospora caninum is a protozoan parasite of animals. Until 1988, it was misidentified as Toxoplasma gondii. Since its first recognition in dogs in 1984 and the description of the new genus and species Neospora caninum in 1988, neosporosis has emerged as a serious disease of cattle and dogs worldwide. Abortions and neonatal mortality are a major problem in livestock operations, and neosporosis is a major cause of abortion in cattle. Although antibodies to N. caninum have been reported, the parasite has not been detected in human tissues. Thus, the zoonotic potential is uncertain. This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated. The role of wildlife in the life cycle of N. caninum and strategies for the control of neosporosis in cattle are discussed.read more
Citations
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Rodent-borne diseases and their risks for public health
TL;DR: A large number of pathogens that are directly or indirectly transmitted by rodents are described and a simplified rodent disease model is discussed.
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Neosporosis in animals--the last five years.
Jitender P. Dubey,Gereon Schares +1 more
TL;DR: This review is focused on current status of neosporosis in animals based on papers published in the last five years and strategies for control and prevention are discussed.
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What is the global economic impact of Neospora caninum in cattle - the billion dollar question.
TL;DR: This estimate of global losses due to N. caninum, with the identification of clear target markets (countries, as well as cattle industries), should provide an incentive to develop treatment options and/or vaccines.
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Australian dingoes are definitive hosts of Neospora caninum.
TL;DR: Oocyst shedding from the intestinal tract of a dingo demonstrates that dingoes are definitive hosts of Neospora caninum and horizontal transmission of N.caninum from dingoes to farm animals and wildlife may occur in Australia.
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Comparative Genomics of the Apicomplexan Parasites Toxoplasma gondii and Neospora caninum: Coccidia Differing in Host Range and Transmission Strategy
Adam J. Reid,Sarah J. Vermont,James Cotton,David Harris,Grant A. Hill-Cawthorne,Stephanie Könen-Waisman,Sophia M. Latham,Tobias Mourier,Rebecca Norton,Michael A. Quail,Mandy Sanders,Dhanasekaran Shanmugam,Amandeep Sohal,James D. Wasmuth,James D. Wasmuth,Brian P. Brunk,Michael E. Grigg,Jonathan C. Howard,John Parkinson,David S. Roos,Alexander J. Trees,Matthew Berriman,Arnab Pain,Arnab Pain,Jonathan M. Wastling +24 more
TL;DR: The ecological niches occupied by these species are influenced by a relatively small number of gene products which operate at the host-parasite interface and that the dominance of vertical transmission in N. caninum may be associated with the evolution of reduced virulence in this species.
References
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Mouse model for central nervous system Neospora caninum infections.
TL;DR: An inbred BALB/c mouse model is reported that results in central nervous system neosporosis in the absence of MPA treatment and some mice in all N. caninum-inoculated groups had brain lesions, but significantly (P < 0.05) more BALb/c mice inoculated with the NC-1 strain hadbrain lesions.
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Isolation of Neospora caninum from the brain of a naturally infected dog, and production of encysted bradyzoites in gerbils
Luis Fernando Pita Gondim,A.M. Pinheiro,P.O.M. Santos,Erica Etelvina Viana de Jesus,Marcos Borges Ribeiro,H.S. Fernandes,Maria Angela Ornelas de Almeida,Songeli Menezes Freire,Roberto Meyer,Milton M. McAllister +9 more
TL;DR: Gerbils may be a useful alternative to immunosuppressed mice for isolation of N. caninum and for production of encysted bradyzoites.
Journal Article
Serologic prevalence of Sarcocystis neurona, Toxoplasma gondii, and Neospora caninum in horses in Brazil.
TL;DR: The high prevalence of antibodies against S neurona detected in clinically normal horses emphasizes the importance of examining CSF for antibodies when establishing a diagnosis of equine protozoal myeloencephalitis.
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Evidence of post-natal transmission of Neospora caninum in Dutch dairy herds
TL;DR: Findings strongly indicate a post-natal infection of the animals in the high seroprevalence age-groups, probably due to a point source exposure to N. caninum.
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Characterization of the first European isolate of Neospora caninum (Dubey, Carpenter, Speer, Topper and Uggla)
TL;DR: A 5-week-old Boxer pup with a progressive hindlimb paresis was diagnosed as suffering from neosporosis on the basis of clinical signs and the presence of anti-Neospora antibodies in it, 2 litter-mates and its dam, and was euthanased 3 days later.