Epidemiology and Control of Neosporosis and Neospora caninum
TLDR
This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated.Abstract:
Neospora caninum is a protozoan parasite of animals. Until 1988, it was misidentified as Toxoplasma gondii. Since its first recognition in dogs in 1984 and the description of the new genus and species Neospora caninum in 1988, neosporosis has emerged as a serious disease of cattle and dogs worldwide. Abortions and neonatal mortality are a major problem in livestock operations, and neosporosis is a major cause of abortion in cattle. Although antibodies to N. caninum have been reported, the parasite has not been detected in human tissues. Thus, the zoonotic potential is uncertain. This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated. The role of wildlife in the life cycle of N. caninum and strategies for the control of neosporosis in cattle are discussed.read more
Citations
More filters
Journal ArticleDOI
Vaccines for bovine neosporosis: current status and key aspects for development
Pilar Horcajo,Javier Regidor-Cerrillo,Adriana Aguado-Martínez,Andrew Hemphill,Luis Miguel Ortega-Mora +4 more
TL;DR: The identification of novel potential targets and vaccines, and the application of innovative vaccine technologies in harmonized experimental animal models, will accelerate the development of an effective vaccine against bovine neosporosis.
Journal ArticleDOI
Host Cells Participate in the In Vitro Effects of Novel Diamidine Analogues against Tachyzoites of the Intracellular Apicomplexan Parasites Neospora caninum and Toxoplasma gondii
TL;DR: In vitro effects of 19 dicationic diamidine derivatives against the proliferative tachyzoite stages of the apicomplexan parasites Neospora caninum and Toxoplasma gondii suggest that either these compounds or their respective active metabolites were still present after the removal of the drugs or the drug treatments reversibly impaired some functional activities in HFFs that were essential for parasite proliferation and/or survival.
Journal ArticleDOI
High rate of transplacental infection and transmission of Neospora caninum following experimental challenge of cattle at day 210 of gestation
Julio Benavides,Frank Katzer,Stephen W. Maley,Paul M. Bartley,Germán J. Cantón,Javier Palarea-Albaladejo,Caroline A. Purslow,Yvonne Pang,Mara Rocchi,Francesca Chianini,David Buxton,Elisabeth A. Innes +11 more
TL;DR: Cattle were subcutaneously challenged with 5 × 108Neospora caninum (NC1 isolate) tachyzoites and serial necropsies suggested that a change in the maternal immune response plays a crucial role in limiting the initial infection during the last term of pregnancy.
Journal ArticleDOI
Serologic screening for 13 infectious agents in roe deer ( Capreolus capreolus ) in Flanders
Paul Tavernier,Stanislas Sys,Kris De Clercq,Ilse De Leeuw,Anne Brigitte Caij,Miet De Baere,Nick De Regge,David Fretin,Virginie Roupie,Marc Govaerts,Paul Heyman,Daisy Vanrompay,Lizi Yin,Isabelle Kalmar,Vanessa Suin,Bernard Brochier,Alexandre Dobly,Stéphane De Craeye,Sophie Roelandt,Els Goossens,Stefan Roels +20 more
TL;DR: Roe deer do not seem to play an important role in the epidemiology of the examined zoonotic and domestic animal pathogens, and their meaning as sentinels should not be neglected in the absence of other wild cervid species.
Journal ArticleDOI
Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion
TL;DR: Structural characterization of AMA1 from the apicomplexan parasites Babesia divergens and Neospora caninum by X‐ray crystallography offers intriguing structural insight into the RON2‐binding surface groove in the AMA1 apical domain, which shows clear evidence for receptor–ligand co‐evolution.
References
More filters
Journal ArticleDOI
Dogs are definitive hosts of Neospora caninum.
Milton M. McAllister,Jitender P. Dubey,David S. Lindsay,Jolley Wr,Rebecca A Wills,McGuire Am +5 more
TL;DR: Dogs are a definitive host of Neospora caninum, and mice inoculated with canine faecal extracts were monitored for evidence of neosporosis using a variety of morphologic, immunohistologic, serologic, and genetic analyses.
Journal ArticleDOI
A review of Neospora caninum and neosporosis
TL;DR: Neospora caninum is a recently recognized protozoan parasite of animals, which until 1988 was misidentified as Toxoplasma gondii, and its life cycle is unknown.
Journal Article
Newly recognized fatal protozoan disease of dogs
TL;DR: A newly identified parasite, Neospora caninum, structurally distinct from T gondii, was found in 10 dogs and formed meronts in many tissues of the dogs, especially the brain and spinal cord.
Journal ArticleDOI
Review of Neospora caninum and neosporosis in animals.
TL;DR: Information on biology, diagnosis, epidemiology and control of neosporosis in animals, a major cause of abortion in cattle in many countries, is reviewed.
Journal Article
Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission.
TL;DR: Neospora caninum infection was diagnosed in 5 young dogs from 2 litters with a common parentage that developed hind limb paresis 5 to 8 weeks after birth and was isolated in cell cultures, mice, and dogs inoculated with infected canine tissues.