Journal ArticleDOI
Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study
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TLDR
The findings challenge the single-disease framework by which most health care, medical research, and medical education is configured, and a complementary strategy is needed, supporting generalist clinicians to provide personalised, comprehensive continuity of care, especially in socioeconomically deprived areas.About:
This article is published in The Lancet.The article was published on 2012-07-07. It has received 4839 citations till now. The article focuses on the topics: Comorbidity & Health services research.read more
Citations
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The World report on ageing and health: a policy framework for healthy ageing.
John R. Beard,Alana Officer,Islene Araujo de Carvalho,Ritu Sadana,Anne Margriet Pot,Jean-Pierre Michel,Peter Lloyd-Sherlock,JoAnne E. Epping-Jordan,Geeske Peeters,Wahyu Retno Mahanani,Jotheeswaran Amuthavalli Thiyagarajan,Somnath Chatterji +11 more
TL;DR: The first World report on ageing and health is released, reviewing current knowledge and gaps and providing a public health framework for action, built around a redefinition of healthy ageing that centres on the notion of functional ability.
Journal ArticleDOI
How to increase value and reduce waste when research priorities are set
Iain Chalmers,Michael B. Bracken,Ben Djulbegovic,Silvio Garattini,Jonathan Grant,A Metin Gülmezoglu,David W. Howells,John P. A. Ioannidis,Sandy Oliver +8 more
TL;DR: This report discusses how avoidable waste can be considered when research priorities are set and recommends ways to improve the yield from basic research, and the transparency of processes by which funders prioritise important uncertainties should be increased.
Journal ArticleDOI
Racism and Health I: Pathways and Scientific Evidence
TL;DR: A large and growing body of evidence indicates that experiences of racial discrimination are an important type of psychosocial stressor that can lead to adverse changes in health status and altered behavioral patterns that increase health risks.
Journal ArticleDOI
Microglial priming in neurodegenerative disease.
V. Hugh Perry,Clive Holmes +1 more
TL;DR: The concept of microglial priming, and the subsequent exaggerated response of these cells to secondary systemic inflammation, opens the way to treat neurodegenerative diseases by targeting systemic disease or interrupting the signalling pathways that mediate the CNS response to systemic inflammation.
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Prevalence, Determinants and Patterns of Multimorbidity in Primary Care: A Systematic Review of Observational Studies
Concepció Violan,Quintí Foguet-Boreu,Gemma Flores-Mateo,Chris Salisbury,Jeanet W. Blom,Michael H. Freitag,Liam G. Glynn,Christiane Muth,Jose M Valderas +8 more
TL;DR: The limitations of the current evidence base means that further and better designed studies are needed to inform policy, research and clinical practice, with the goal of improving health-related quality of life for patients with multimorbidity.
References
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Journal ArticleDOI
Causes and consequences of comorbidity: a review.
Gijsen R,Nancy Hoeymans,François G. Schellevis,Dirk Ruwaard,William A. Satariano,Geertrudis A.M. van den Bos +5 more
TL;DR: It is found comorbidity in general to be associated with mortality, quality of life, and health care, and the consequences of specific disease combinations depended on many factors.
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Eligibility criteria of randomized controlled trials published in high-impact general medical journals: a systematic sampling review.
TL;DR: The RCTs published in major medical journals do not always clearly report exclusion criteria and justification for exclusions related to concomitant medication use, medical comorbidities, female sex, and socioeconomic status were more likely to be poorly justified.
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Prevalence of Multimorbidity Among Adults Seen in Family Practice
TL;DR: The prevalence of multimorbidity in family practice patients is quite high and increases significantly with age in both men and women, whether measured by simply counting the number of conditions or using the Cumulative Illness Rating Scale (CIRS).
Prevalence of Multimorbidity Among Adults Seen in Family Practice
TL;DR: In this paper, the authors estimate the prevalence of multimorbidity in primary care patients by counting the number of chronic medical conditions and using a measure that considers the severity of these conditions, the Cumulative Illness Rating Scale (CIRS).
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Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study
TL;DR: Multimorbidity is common in the population and most consultations in primary care involve people with multi- chronic conditions, but these people are less likely to receive continuity of care, although they may be more likely to gain from it.