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Journal ArticleDOI

Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study

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TLDR
The findings challenge the single-disease framework by which most health care, medical research, and medical education is configured, and a complementary strategy is needed, supporting generalist clinicians to provide personalised, comprehensive continuity of care, especially in socioeconomically deprived areas.
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This article is published in The Lancet.The article was published on 2012-07-07. It has received 4839 citations till now. The article focuses on the topics: Comorbidity & Health services research.

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Citations
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Prevalence of Patients Eligible for Anti-IL-5 Treatment in a Cohort of Adult-Onset Asthma

TL;DR: Both groups represent a high burden to health care and specifically targeted treatment could lead to lower use of health care at long term.
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Managing multimorbidity in primary care in patients with chronic respiratory conditions.

TL;DR: A primary care physician has the challenging role of integrating all of the clinical problems affecting the patient and reviewing all medicaments taken by the patient at any point in time, and has the key to prevent the unwanted consequences of polypharmacy.
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Public policy response, aging in place, and big data platforms: Creating an effective collaborative system to cope with aging of the population.

TL;DR: Advances in information and communications technology, assistive devices, medical diagnostics, and interventions offer many ways of more efficiently providing long-term care as part of aging in place, but the use of big data in collaborative system is a double-edged sword.
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Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target.

TL;DR: This review explores the current scientific evidence for inflammation, cellular ageing and cellular processes, such as reactive oxygen species production and phenotypic changes in the pathogenesis of COPD, T2D and atherosclerosis; highlighting common mechanisms shared across these diseases.
References
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Contribution of Primary Care to Health Systems and Health

TL;DR: The means by which primary care improves health have been identified, thus suggesting ways to improve overall health and reduce differences in health across major population subgroups.
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Social determinants of health inequalities

TL;DR: A Commission on Social Determinants of Health is launching, which will review the evidence, raise societal debate, and recommend policies with the goal of improving health of the world's most vulnerable people.
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Depression, chronic diseases, and decrements in health: results from the World Health Surveys

TL;DR: Depression produces the greatest decrement in health compared with the chronic diseases angina, arthritis, asthma, and diabetes, and the urgency of addressing depression as a public-health priority is indicated to improve the overall health of populations.
Journal Article

Depression, chronic diseases, and decrements in health : results from the world health surveys. Commentary

TL;DR: In this paper, the authors explored the effect of depression, alone or as a comorbidity, on overall health status and found that depression produces the greatest decrement in health compared with the chronic diseases angina, arthritis, asthma, and diabetes.
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Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance.

TL;DR: It is suggested that adhering to current CPGs in caring for an older person with several comorbidities may have undesirable effects and could create perverse incentives that emphasize the wrong aspects of care for this population and diminish the quality of their care.
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