Journal ArticleDOI
Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer: II. Relationship between receptor expression and response to epidermal growth factor
Gustavo C. Rodriguez,Andrew Berchuck,Regina S. Whitaker,David Schlossman,Daniel L. Clarke-Pearson,Robert C. Bast +5 more
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TLDR
This study found that epidermal growth factor stimulated twofold to fourfold increases in proliferation in epithelial cells from each of five normal ovaries (p) in monolayer culture.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1991-03-01. It has received 113 citations till now. The article focuses on the topics: Epidermal growth factor & Growth factor receptor inhibitor.read more
Citations
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Journal ArticleDOI
Cancer of the Ovary
TL;DR: The clinical features of ovarian cancer and recent advances in postoperative management are described, including bilateral salpingo-oophorectomy in selected women.
Journal ArticleDOI
Ovarian surface epithelium: biology, endocrinology, and pathology.
TL;DR: The objective of this article is to review the cellular and molecular mechanisms that underlie the control of normal and neoplastic OSE cell growth, differentiation, and expression of indicators of neoplastics progression.
Journal Article
Lysophosphatidic Acid Promotes Matrix Metalloproteinase (MMP) Activation and MMP-dependent Invasion in Ovarian Cancer Cells
TL;DR: Treatment of ovarian cancer cells with pathophysiological levels of LPA increased cellular adhesion to type I collagen and beta1 integrin expression and a significant up-regulation of MMP-dependent proMMP-2 activation was observed in LPA-treated cells, leading to enhanced pericellular MMP activity.
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Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells.
Silvia Misiti,Simona Nanni,Giulia Fontemaggi,Yu-Sheng Cong,Jianping Wen,Hal W. Hirte,Giulia Piaggio,Ada Sacchi,Alfredo Pontecorvi,Silvia Bacchetti,Antonella Farsetti +10 more
TL;DR: The identification of hTERT as a target of estrogens represents a novel finding which advances the understanding of telomerase regulation in hormone-dependent cells and has implications for a potential role of hormones in their senescence and malignant conversion.
Journal ArticleDOI
The prognostic value of epidermal growth factor receptor mRNA expression in primary ovarian cancer.
J. M. S. Bartlett,Simon P. Langdon,B. J. B. Simpson,M. Stewart,Dionyssios Katsaros,P. Sismondi,Sharon Love,W. N. Scott,Alistair R.W. Williams,A M Lessells,Kenneth G. MacLeod,John F. Smyth,William R. Miller +12 more
TL;DR: The survival of patients with malignant tumours possessing EGF receptor mRNA was significantly reduced compared with that of patients whose tumours were negative and neither the expression of TGF-alpha nor EGF was related to survival.
References
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Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer
TL;DR: EGFR status divides the ER- population into good and poor prognosis subgroups, and the presence of EGFR was the most important variable in the primary tumours for predicting relapse-free and overall survival.
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Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors
TL;DR: Three different human tumor lines in culture, a rhabdomyosarcoma, a bronchogenic carcinoma and a metastatic melanoma, release proteins (transforming growth factors, TGFs) into the medium that confer the transformed phenotype on untransformed fibroblasts that enable normal anchorage-dependent cells to grow in agar.
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Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas.
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Relation of epidermal growth factor receptor concentration to growth of human epidermoid carcinoma A431 cells.
TL;DR: It is indicated that in A431 cell variants a continuum of ligand-activated EGF receptors determines proliferative responses from low concentrations of active receptors under basal conditions to intermediate concentrations causing growth stimulation to high concentrations, causing inhibition of cell proliferation.