Evaluation of reversible contraceptive potential of Cordia dichotoma leaves extract
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The observations suggested that the developed phyto-pharmaceutical has potential antifertility activity with safety aspects and the reversible contraceptive potential after withdrawal.Abstract:
Considering the safety-risk ratio of steroidal contraceptives, the present work was carried out to evaluate ethno-contraceptive use of Cordia dichotoma G Forst, Boraginaceae, leaves (LCD) Preliminary pharmacological screening was performed on post-coital female albino rats The leaves extract (LD50 550 g/kg bw) showed 100% anti-implantation activity (n=10) at 800 mg/kg dose level (2-hydroxypropyl)-β-cyclodextrin (BCD) was used as bioavailability enhancer to form LCD-BCD complex, characterized by DLS, SEM and XRD analyses The LCD-BCD complex (1:1, w/w) exhibited 100% pregnancy interception (n=20) at the dose level of 250 mg/kg and also showed strong estrogenic potential with a luteal phase defect Qualitative and quantitative phytochemical analyses were carried out The LCD extract was standardized by a validated HPTLC method and two contraceptive phytoconstituents, apigenin and luteolin were isolated A detailed pharmacological analyses followed by chronic toxicity study were performed to predict the reversible nature of the developed phytopharmaceutical The histological and biochemical estimations detected the reversible contraceptive potential after withdrawal The observations suggested that the developed phyto-pharmaceutical has potential antifertility activity with safety aspectsread more
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Automatic Early Diagnosis of Dome Galls in Cordia Dichotoma G. Forst. Using Deep Transfer Learning
TL;DR: In this article , a DL model, Yolov4, has been modified and is trained for the early detection of dome galls in the leaves of Cordia dichotoma G. early.
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Sperm quality and testicular histopathology of Wistar albino male rats treated with hydroethanolic extract of Cordia dichotoma fruits
Samah A El-Newary,Mohamed S. A. Aly,Amal R. Abd El Hameed,Mohamed Kotp,Abdelghany A Youssef,Naglaa A Ali +5 more
TL;DR: Cordia antifertility effect may be due to its hypocholesterolemic effect, where cholesterol, the steroid cycle precursor, was significantly reduced.
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Ethno-medico-botanical studies of Eruliga and Lambani tribes of Kanakapura taluk of Ramanagara district of Karnataka
TL;DR: A field survey and documentation of indigenous medicinal knowledge and medicinal plants was conducted from September 2019 to March 2022 as discussed by the authors , where a total of 417 formulations consisting of 217 medicinal plants practiced by 140 traditional practitioners were documented.
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A comprehensive Review on Ethnopharmacology and Phytochemistry of an Underutilized Plant Cordia dichotoma L
TL;DR: The elaborative results vindicate that extracts and phytoconstituents from C. dichotoma exert a wide spectrum of pharmacological effects and hold significant prospects in major health conditions.
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