Evaluation of reversible contraceptive potential of Cordia dichotoma leaves extract
TLDR
The observations suggested that the developed phyto-pharmaceutical has potential antifertility activity with safety aspects and the reversible contraceptive potential after withdrawal.Abstract:
Considering the safety-risk ratio of steroidal contraceptives, the present work was carried out to evaluate ethno-contraceptive use of Cordia dichotoma G Forst, Boraginaceae, leaves (LCD) Preliminary pharmacological screening was performed on post-coital female albino rats The leaves extract (LD50 550 g/kg bw) showed 100% anti-implantation activity (n=10) at 800 mg/kg dose level (2-hydroxypropyl)-β-cyclodextrin (BCD) was used as bioavailability enhancer to form LCD-BCD complex, characterized by DLS, SEM and XRD analyses The LCD-BCD complex (1:1, w/w) exhibited 100% pregnancy interception (n=20) at the dose level of 250 mg/kg and also showed strong estrogenic potential with a luteal phase defect Qualitative and quantitative phytochemical analyses were carried out The LCD extract was standardized by a validated HPTLC method and two contraceptive phytoconstituents, apigenin and luteolin were isolated A detailed pharmacological analyses followed by chronic toxicity study were performed to predict the reversible nature of the developed phytopharmaceutical The histological and biochemical estimations detected the reversible contraceptive potential after withdrawal The observations suggested that the developed phyto-pharmaceutical has potential antifertility activity with safety aspectsread more
Citations
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Journal ArticleDOI
Traditional uses, phytochemistry and pharmacology of the medicinal species of the genus Cordia (Boraginaceae).
TL;DR: The aim of this review was to provide exhaustive scientific information on traditional uses, phytochemistry and pharmacological activities of the 36 important species with medicinal value from the genus Cordia to divulge prospects for further research on its therapeutic potential.
Journal ArticleDOI
The genus Cordia: botanists, ethno, chemical and pharmacological aspects
Edinardo F.F. Matias,Erivania F. Alves,Maria Karollyna do Nascimento Silva,Victoria Regina de Alencar Carvalho,Henrique Douglas Melo Coutinho,José Galberto Martins da Costa +5 more
TL;DR: The principal botanical aspects, ethnopharmacological information and evaluation of the bioactive and pharmacological properties of Cordia, its phytochemical constituents and the most common classes of secondary metabolites identified are described.
The genus Cordia: botanists, ethno, chemical and pharmacological
TL;DR: In this paper, the authors describe the principal botanical aspects, ethnopharmacological information and evaluation of the bioactive and pharmacological properties of Cordia, itsphytochemicalconstituents and the most common classes of secondary metabolites identified.
Journal ArticleDOI
Isolation and Characterization of New Phenolic Compounds with Estrogen Biosynthesis-Inhibiting and Antioxidation Activities from Broussonetia papyrifera Leaves
TL;DR: Findings suggest that BPL may improve meat quality through the regulation of estrogen biosynthesis and may be useful for the discovery of potential aromatase modulators from natural products.
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In Vitro susceptibilities of wild and drug resistant Leishmania donovani amastigotes to piperolactam A loaded hydroxypropyl-β-cyclodextrin nanoparticles.
Plaban Bhattacharya,Plaban Bhattacharya,Subhasish Mondal,Souvik Basak,Pradeep Das,Achintya Saha,Tanmoy Bera +6 more
TL;DR: Piperolactam A (PL), a representative of the inchoate skeleton of aristolactAM chassis might be the source of safe and affordable antileishmanial agents for the cure of deadly Leishmania infections.
References
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Use of apigenin from Cordia dichotoma in the treatment of colitis.
TL;DR: It can be concluded that apigenin from C. dichotoma bark may be responsible for the treatment of UC.
Journal ArticleDOI
Essential and toxic trace elements in the Chinese medicine
TL;DR: The concentration of certain toxic and essential elements in various raw materials of Chinese herbs and scientific Chinese medicine were determined by atomic absorption spectrometry (AAS) and instrumental neutron activation analysis (INAA) as discussed by the authors.
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A review on potentiality of medicinal plants as the source of new contraceptive principles
TL;DR: This review embraces the natural contraceptives upto year 2001 with 355 references and includes the isolation of their active principles, methods of analysis of active ingredients through TLC, HPLC, their side effects and pharmacological action.
Book ChapterDOI
Food and Drug Administration, US
TL;DR: This article is a revision of the previous edition article by Ankur V. Dnyanmote and Harihara M. Mehendale, volume 4, pp 516–517, © 2005, Elsevier Inc.
Journal ArticleDOI
Diversity, Distribution Pattern and Conservation Status of the Plants Used in Liver Diseases/Ailments in Indian Himalayan Region
S. S. Samant,Shreekar Pant +1 more
TL;DR: Assessment of the populations of threatened species, development of an appropriate strategy, action plan for the conservation and sustainable utilization of such components of plant diversity are suggested.