Journal ArticleDOI
Evidence for the specificity of intracortical inhibitory dysfunction in asymptomatic concussed athletes.
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TLDR
It is suggested that multiple sports concussions lead to specific, long-term neurophysiological dysfunctions of intracortical inhibitory mechanisms in primary motor cortex while somatosensory processing and sensorimotor integration are spared.Abstract:
Sports concussions affect thousands of individuals every year and are a major public health concern. Still, little is known about the long-term and cumulative effects of concussions on brain neurophysiology. The principal objective of this study was to investigate the long-lasting effects of multiple sports concussions on sensorimotor integration and somatosensory processing in a sample of 12 concussed athletes and 14 non-concussed athletes of similar age (mean, 23 years) and education (mean, 16 years). Right median nerve stimulation was paired with transcranial magnetic stimulation (TMS) of the left primary motor cortex to investigate sensorimotor integration with short latency afferent inhibition (SAI) and long latency afferent inhibition (LAI) at five interstimulus intervals (18, 20, 22, 100, 200 msec). Somatosensory evoked potentials (SEP) were recorded from the left centro-parietal region. We also investigated primary motor cortex inhibitory mechanisms with three TMS protocols: cortical sile...read more
Citations
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Journal ArticleDOI
Musculoskeletal Injury Risk After Sport-Related Concussion: A Systematic Review and Meta-analysis.
TL;DR: Standard clinical assessments for athletes with concussion should include not only physical symptoms and cognitive function before return to sport but also neuromuscular risk factors associated with increased risk for MSK injuries.
Journal ArticleDOI
Altered Bidirectional Plasticity and Reduced Implicit Motor Learning in Concussed Athletes
Louis De Beaumont,Louis De Beaumont,Sébastien Tremblay,Judes Poirier,Maryse Lassonde,Hugo Théoret +5 more
TL;DR: These findings identify GABA neurotransmission alterations after repeated concussive injuries and suggest that impaired learning after multiple concussions could at least partly be related to compromised GABA-dependent LTP/LTD synaptic plasticity.
Journal ArticleDOI
The EEG correlates of the TMS-induced EMG silent period in humans
Faranak Farzan,Mera S. Barr,Sylco S. Hoppenbrouwers,Paul B. Fitzgerald,Robert Chen,Alvaro Pascual-Leone,Alvaro Pascual-Leone,Zafiris J. Daskalakis +7 more
TL;DR: It is demonstrated that the duration of SP is related to the temporal characteristics of the cortical reactivity and the power of delta to alpha oscillations in both local and remote areas ipsilateral and contralateral to the stimulation site, and beta oscillations locally.
Journal ArticleDOI
Postconcussion Syndrome: A Review.
TL;DR: The relative contribution of injury factors to postconcussion syndrome decreases over time and, instead, premorbid factors become important predictors of symptom persistence by 3 to 6 months postinjury.
Journal ArticleDOI
Non-invasive brain stimulation in children: applications and future directions.
Thilinie Rajapakse,Adam Kirton +1 more
TL;DR: TMS represents an exciting advancement to better understand and improve outcomes from disorders of the developing brain and is an enviable technology for use in pediatric research with future extension into therapeutic trials.
References
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