Journal ArticleDOI
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
TLDR
It is suggested that release of oxytocin from a descending pPVN-to-NTS pathway contributes to leptin's attenuation of food intake by a mechanism that involves the activation of pPvN oxytoc in neurons by leptin, resulting in increased sensitivity of NTS neurons to satiety signals.Abstract:
Hindbrain projections of oxytocin neurons in the parvocellular paraventricular nucleus (pPVN) are hypothesized to transmit leptin signaling from the hypothalamus to the nucleus of the solitary trac...read more
Citations
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Journal ArticleDOI
Central nervous system control of food intake and body weight
TL;DR: This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.
Journal ArticleDOI
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Nina Balthasar,Louise Torp Dalgaard,Charlotte E. Lee,Jia Yu,Hisayuki Funahashi,Todd D. Williams,Manuel A. R. Ferreira,Vinsee Tang,Robert A. McGovern,Christopher D. Kenny,Lauryn M. Christiansen,Elizabeth Edelstein,Brian Choi,Olivier Boss,Carl J. Aschkenasi,Chen-Yu Zhang,Kathleen G. Mountjoy,Toshiro Kishi,Toshiro Kishi,Joel K. Elmquist,Bradford B. Lowell +20 more
TL;DR: It is demonstrated thatMC4Rs in the PVH and/or the amygdala control food intake but that MC4Rs elsewhere control energy expenditure, and association of food intake and energy expenditure reveals unexpected divergence in melanocortin pathways controlling energy balance.
Journal ArticleDOI
Neurobiology of food intake in health and disease.
TL;DR: How the interplay between homeostatic and emergency feeding circuits influences the biologically defended level of body weight under physiological and pathophysiological conditions is highlighted.
Journal ArticleDOI
Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance.
Harvey J. Grill,Matthew R. Hayes +1 more
TL;DR: This Review highlights the processing and integration performed by hindbrain nuclei, focusing on the inputs received by nucleus tractus solitarius (NTS) neurons, and proposes that NTS (and hindbrain neurons, more broadly) integrate these multiple energy status signals and issue-output commands controlling the behavioral, autonomic, and endocrine responses that collectively govern energy balance.
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The expectant brain: adapting for motherhood
Paula J. Brunton,John A. Russell +1 more
TL;DR: A successful pregnancy requires multiple adaptations of the mother's physiology to optimize fetal growth and development, to protect the fetus from adverse programming, to provide impetus for timely parturitions and to ensure that adequate maternal care is provided after parturition.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
The Rat Brain in Stereotaxic Coordinates, George Paxinos, Charles Watson (Eds.). Academic Press, San Diego, CA (1982), vii + 153, $35.00, ISBN: 0 125 47620 5
TL;DR: It is shown here how the response of the immune system to repeated exposure to high-energy radiation affects its ability to discriminate between healthy and diseased tissue.
Journal ArticleDOI
Central nervous system control of food intake
TL;DR: A model is described that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.
Journal ArticleDOI
Role of leptin in the neuroendocrine response to fasting
Rexford S. Ahima,Daniel Prabakaran,Christos S. Mantzoros,Daqing Qu,Bradford B. Lowell,Eleftheria Maratos-Flier,Jeffrey S. Flier +6 more
TL;DR: It is proposed that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin, and preventing the starvation-induced fall in leptin with exogenous leptin substantially blunts the changes in gonadal, adrenal and thyroid axes in male mice, and prevents the starve-induced delay in ovulation in female mice.
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The rat brain in stereotaxic coordinates (2nd edn): by George Paxinos and Charles Watson, Academic Press, 1986. £40.00/$80.00 (264 pages) ISBN 012 547 6213
TL;DR: The second editon of Paxinos and Watson's rat stereotaxic atlas is, like the first, an indispensable commodity for neuroscientists utilizing rodent models for research as well as for students learning basic fundamentals of rat brain neuroanatomy.