Journal ArticleDOI
Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase.
Kohji Wake,Hajime Yamazaki,Shinji Hanzawa,Ryuichi Konno,Hideaki Sakio,Akira Niwa,Yuuichi Hori +6 more
TLDR
The present observations provide another line of evidence that D-serine functions as an endogenous coagonist at the glycine site of NMDA receptors, and raise the possibility that D -amino-acid oxidase exerts a neuromodulatory function by controlling the concentration of D- Serine in the central nervous system.About:
This article is published in Neuroscience Letters.The article was published on 2001-01-05. It has received 86 citations till now. The article focuses on the topics: NMDA receptor & Neurotransmission.read more
Citations
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Journal ArticleDOI
Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
Thomas Papouin,Laurent Ladépêche,Laurent Ladépêche,Jérôme Ruel,Jérôme Ruel,Silvia Sacchi,Marilyne Labasque,Marwa Hanini,Laurent Groc,Laurent Groc,Loredano Pollegioni,Jean-Pierre Mothet,Stéphane H. R. Oliet,Stéphane H. R. Oliet +13 more
TL;DR: It is demonstrated that long-term potentiation and NMDA-induced neurotoxicity rely on synaptic NMDARs only, and long- term depression requires both synaptic and extrasynaptic receptors.
Journal ArticleDOI
Molecular mechanisms of schizophrenia.
TL;DR: Molecular findings suggest that a complex interplay between receptors, kinases, proteins and hormones is involved in schizophrenia and in a unifying hypothesis, different cascades merge into another that ultimately lead to the development of symptoms adherent to schizophrenic disorders.
Journal ArticleDOI
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase
John Mitchell,Praveen Paul,Han-Jou Chen,Alex G. Morris,Miles Payling,Mario Falchi,JJ Habgood,Stefania Panoutsou,Sabine Winkler,Veronica Tisato,Amin Hajitou,Bradley N. Smith,Caroline Vance,Christopher Shaw,Nicholas D. Mazarakis,Jacqueline de Belleroche +15 more
TL;DR: A unique mutation in the D-amino acid oxidase gene (R199W DAO) associated with classical adult onset familial amyotrophic lateral sclerosis (FALS) in a three generational FALS kindred is reported, after candidate gene screening in a 14.52 cM region on chromosome 12q22-23 linked to disease.
Journal ArticleDOI
D-amino acids in the central nervous system in health and disease.
TL;DR: The presence and important roles of d-amino acids in higher organisms do not only challenge former theories on mammalian physiology, but also contribute to exciting new insights in human disease.
Journal ArticleDOI
D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning.
TL;DR: D-serine may enhance a form of hippocampal NR2B-dependent LTD that contributes to spatial reversal learning, which could improve cognitive flexibility in psychiatric disorders characterized by perseveration of aberrant ideation or behaviors.
References
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Journal ArticleDOI
Glycine potentiates the NMDA response in cultured mouse brain neurons
J. W. Johnson,P Ascher +1 more
TL;DR: G glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor, and can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
Journal ArticleDOI
Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
TL;DR: In voltage-clamped oocytes, neither perfusion nor rapid pressure application of NMDA onto messenger RNA-injected oocytes caused a distinct ionic current without added glycine, but when glycine was added, NMDA evoked large inward currents.
Journal ArticleDOI
d-Serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor
Jean-Pierre Mothet,Angèle T. Parent,Angèle T. Parent,Herman Wolosker,Roscoe O. Brady,David J. Linden,Christopher D. Ferris,Michael A. Rogawski,Solomon H. Snyder +8 more
TL;DR: D-serine is an endogenous modulator of the glycine site of NMDA receptors and fully occupies this site at some functional synapses and greatly attenuates NMDA receptor-mediated neurotransmission as assessed by using whole-cell patch-clamp recordings or indirectly by using biochemical assays of the sequelae of NMda receptor- mediated calcium flux.
Journal ArticleDOI
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.
TL;DR: D-Serine appears to be the endogenous ligand for the glycine site of NMDA receptors, suggesting a mechanism by which astrocyte-derived D-serine could modulate neurotransmission.
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