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Exercise and Sports Science Australia (ESSA) position statement on exercise prescription for the prevention and management of osteoporosis

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TLDR
Evidence from animal and human trials indicates that bone responds positively to impact activities and high intensity progressive resistance training, and the optimisation of muscle strength, balance and mobility minimises the risk of falls.
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This article is published in Journal of Science and Medicine in Sport.The article was published on 2017-05-01 and is currently open access. It has received 208 citations till now. The article focuses on the topics: Exercise prescription & Osteoporosis.

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Resistance Training for Older Adults: Position Statement From the National Strength and Conditioning Association.

TL;DR: Evidence is provided to support recommendations for successful resistance training in older adults related to 4 parts: program design variables, physiological adaptations, functional benefits, and considerations for frailty, sarcopenia, and other chronic conditions.
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Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms

TL;DR: It is proposed that physical inactivity could be considered a behavior selected by evolution for resting, and also selected to be reinforcing in life-threatening situations in which exercise would be dangerous.
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The Exercise and Sports Science Australia position statement: Exercise medicine in cancer management

TL;DR: There is no set prescription and total weekly dosage that would be considered evidence-based for all cancer patients, so targeted exercise prescription is needed to ensure greatest benefit in the short and longer term, with low risk of harm.
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International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines

TL;DR: In this paper, the authors provide evidence-based rationale for using exercise and physical activity (PA) for health promotion and disease prevention and treatment in older adults, and discuss the specific modalities and doses that have been studied in randomised controlled trials for their effectiveness in attenuating physiological changes of ageing, disease prevention, and/or improvement of older adults with chronic disease and disability.
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Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures

TL;DR: Guidance is provided in an international setting on the assessment and specific treatment of postmenopausal women at low, high and very high risk of fragility fractures as mentioned in this paper, taking additional account of further categorisation of increased risk of fracture.
References
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Journal ArticleDOI

Participation in road cycling vs running is associated with lower bone mineral density in men

TL;DR: Current bone loading is an important determinant of whole-body and lumbar spine BMD and should be sustained during adulthood to maintain bone mass, according to the results of this study.
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High intensity activities in young women: site specific bone mass effects among female figure skaters

TL;DR: Although the skaters were thinner and significantly more likely to have oligo- or amenorrhea, they had similar skeletal densities at upper body sites (spine, arms, ribs) and significantly greater densities in the pelvis and legs, suggesting that there is little likelihood of selection bias as the cause of the observed differences.
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Effects of ground and joint reaction force exercise on lumbar spine and femoral neck bone mineral density in postmenopausal women: a meta-analysis of randomized controlled trials

TL;DR: The overall findings suggest that exercise may result in clinically relevant benefits to FN and LS BMD in postmenopausal women and appear worthy of further investigation in well-designed randomized controlled trials.
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Effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial

TL;DR: A multi-component community-based exercise program was effective for increasing FN BMD in older men, but additional calcium–vitamin D3 did not enhance the osteogenic response.
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Optimum frequency of exercise for bone health: randomised controlled trial of a high-impact unilateral intervention

TL;DR: Brief, daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective and brief high-impact exercise may have a role in reducing hip fragility, but may need to be performed frequently for optimal response.
Related Papers (5)
Frequently Asked Questions (16)
Q1. What are the main causes of falls?

As falls are a major cause of fracture, gait, balance, mobility, transfer ability, range of motion, muscle strength (particularly of the trunk, elbow, hip and knee extensors) and vision should also be considered. 

Progressively challenging balance, posture and mobility exercises should be a greater focus than for low-risk individuals, to prevent falls. 

As kyphotic posture is associated with impaired balance in the elderly with osteoporosis 57 , back extension exercise may indirectly reduce falls risk. 

In light of the strong association between falls and osteoporotic fractures, any exercise programdesigned to prevent fractures in the elderly, particularly those with known risk factors for falling, should include activities to optimise muscle function, balance and gait stability. 

As bone is a dynamic tissue with the capacity to adapt to changing load requirements, exercise iswidely recognised as a vital physical stimulus for the development and maintenance of optimal bone strength throughout life. 

It has been estimated that to power the definitive exercise intervention trial for a hip fracture endpoint in women, a sample size of over 7000 individuals at high risk of low trauma fracture would be required, which would take many years to recruit at a prohibitive financial cost 76 . 

Osteoporotic fracture can occur at virtually any skeletal site; however, the bones most frequently affected are the spine, hip, wrist, humerus and pelvis. 

Some exercise programs that have combined both high intensity PRT and moderate-to-high impact activities such as running, jumping, skipping and high impact aerobics have improved multiple musculoskeletal outcomes for both older women and men, including BMD, and muscle mass, strength and function 48, 49 . 

Many trials have reported relatively modest benefits of exercise to BMD in adulthood - preventing loss or promoting gains in the order of only 1-3% following exerciseinterventions of between 24 and 104 weeks 32 . 

RCTs and meta-analyses indicate that exercise training involving certain forms of weight-bearing impact exercise, such as hopping and jumping, and/or progressive resistance training (PRT), alone or in combination (multi-modal programs), can improve the bone health of children and adolescents 28 , pre29 and postmenopausal women 30 , and older men 31 . 

Individuals with known vertebralosteoporosis/kyphosis should avoid deep forward flexion activities, particularly when lifting a load or carrying an object (e.g. rowing, lifting weights with a flexed spine, yoga, Pilates, bowling, sit-ups, house and yard work), in order to avoid vertebral wedge fractures. 

high-impact activities and exercises that require rapid and/or loaded twisting, and explosive or abrupt actions (e.g., golf, racquet sports) may be contraindicated for some individuals at high risk of low trauma fracture, particularly those with vertebral osteoporosis, poor balance, or osteoarthritis. 

There is also evidence that the inclusion of walking in an exercise program can expose previously sedentary or frail older adults to an increased risk of falling, thereby increasing the risk of fracture 13 . 

More feasible activities to optimise bone health at different stages of life have been examined in randomised controlled trials (RCTs) designed to employ the principles of optimal loading from animal studies. 

In most cases, falls prevention programs that are focused on balance and mobility, including Tai Chi or the well-known Otago Home Exercise Program, do not induce the necessary bone strain to stimulate adaptive skeletal benefits in older people 51, 52 , but may play a vital role in neuromuscular conditioning 53 . 

Relatively few impacts (10-50/day, 3 times/week) 42 are required to stimulate the response in premenopausal women, but added benefit may be derived from more frequent exposure (4-7 days/week) 43 .