Journal ArticleDOI
Experimental characterization of hydrodynamic dispersion in shallow microchannels
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TLDR
Hydrodynamic dispersion in shallow microchannels with almost parabolic cross-sectional shapes and with heights much less than their widths is studied experimentally and it is demonstrated that the dispersion depends on the width rather than the height of the channel.Abstract:
Hydrodynamic dispersion in shallow microchannels with almost parabolic cross-sectional shapes and with heights much less than their widths is studied experimentally. Both long serpentine channels and rotary mixers are used. The experimental results demonstrate that the dispersion depends on the width rather than the height of the channel. The results are in quantitative agreement with a recently proposed theory of dispersion in shallow channels.read more
Citations
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Laminar dispersion at high Péclet numbers in finite-length channels: Effects of the near-wall velocity profile and connection with the generalized Leveque problem
TL;DR: In this paper, the authors developed the theory of laminar dispersion in finite-length channel flows at high Peclet numbers, completing the classical Taylor-Aris theory which applies for long-term, long-distance properties.
Journal ArticleDOI
Droplet formation in a T-shaped microfluidic junction
Haihu Liu,Yonghao Zhang +1 more
TL;DR: In this paper, a phase-field model to describe fluid/fluid interfacial dynamics and a lattice Boltzmann model to address hydrodynamics were used to understand the mechanisms of droplet formation in microfluidic T-junction.
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Droplet formation in microfluidic cross-junctions
Haihu Liu,Yonghao Zhang +1 more
TL;DR: Using a lattice Boltzmann multiphase model, three-dimensional numerical simulations have been performed to understand droplet formation in microfluidic cross-junctions at low capillary numbers as mentioned in this paper.
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Micro-optics for microfluidic analytical applications
TL;DR: This critical review summarizes the developments in the integration of micro-optical elements with microfluidic platforms for facilitating detection and automation of bio-analytical applications, with an emphasis on the realization of optical waveguides and microlenses.
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Integrating whole transcriptome assays on a lab-on-a-chip for single cell gene profiling.
Nathalie Bontoux,Luce Dauphinot,Tania Vitalis,Vincent Studer,Yong Chen,Jean Rossier,M.-C. Potier +6 more
TL;DR: It is demonstrated that, using the microfluidic protocol, 74% of the genes expressed in mouse brain were detected, while only 4% were found with the conventional approach, demonstrating the outstanding sensitivity of the micro fluidic method.
References
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Journal ArticleDOI
Dispersion of soluble matter in solvent flowing slowly through a tube
TL;DR: In this paper, it was shown analytically that the distribution of concentration produced in this way is centred on a point which moves with the mean speed of flow and is symmetrical about it in spite of the asymmetry of the flow.
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Monolithic microfabricated valves and pumps by multilayer soft lithography
TL;DR: An extension to the soft lithography paradigm, multilayersoft lithography, with which devices consisting of multiple layers may be fabricated from soft materials is described, to build active microfluidic systems containing on-off valves, switching valves, and pumps entirely out of elastomer.
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Microfluidics: Fluid physics at the nanoliter scale
Todd M. Squires,Stephen R. Quake +1 more
TL;DR: A review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena as mentioned in this paper.
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Chaotic Mixer for Microchannels
Abraham D. Stroock,Stephan K. W. Dertinger,Armand Ajdari,Igor Mezic,Howard A. Stone,George M. Whitesides +5 more
TL;DR: This work presents a passive method for mixing streams of steady pressure-driven flows in microchannels at low Reynolds number, and uses bas-relief structures on the floor of the channel that are easily fabricated with commonly used methods of planar lithography.
Journal ArticleDOI
On the Dispersion of a Solute in a Fluid Flowing through a Tube
TL;DR: In this paper, it was shown that the rate of growth of the variance is proportional to the sum of the molecular diffusion coefficient and the Taylor diffusion coefficient, where U is the mean velocity and a is a dimension characteristic of the cross-section of the tube.