Fasting and cancer: molecular mechanisms and clinical application
TLDR
It is proposed that the combination of FMDs with chemotherapy, immunotherapy or other treatments represents a potentially promising strategy to increase treatment efficacy, prevent resistance acquisition and reduce side effects.Abstract:
The vulnerability of cancer cells to nutrient deprivation and their dependency on specific metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) lead to wide alterations in growth factors and in metabolite levels, generating environments that can reduce the capability of cancer cells to adapt and survive and thus improving the effects of cancer therapies. In addition, fasting or FMDs increase resistance to chemotherapy in normal but not cancer cells and promote regeneration in normal tissues, which could help prevent detrimental and potentially life-threatening side effects of treatments. While fasting is hardly tolerated by patients, both animal and clinical studies show that cycles of low-calorie FMDs are feasible and overall safe. Several clinical trials evaluating the effect of fasting or FMDs on treatment-emergent adverse events and on efficacy outcomes are ongoing. We propose that the combination of FMDs with chemotherapy, immunotherapy or other treatments represents a potentially promising strategy to increase treatment efficacy, prevent resistance acquisition and reduce side effects.read more
Citations
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Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TL;DR: Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.
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Methionine metabolism in health and cancer: a nexus of diet and precision medicine
TL;DR: A link between nutrition and tumour cell metabolism that may allow for tumour-specific metabolic vulnerabilities that can be influenced by diet is established and the potential of targeting methionine metabolism in cancer through dietary or pharmacological intervention is discussed.
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Dietary modifications for enhanced cancer therapy
TL;DR: The results discussed indicate that the dietary habits and nutritional state of a patient must be taken into account during cancer research and therapy.
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Metabolomics in cancer research and emerging applications in clinical oncology.
Daniel R. Schmidt,Daniel R. Schmidt,Rutulkumar Patel,David G. Kirsch,Caroline A. Lewis,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Jason W. Locasale +7 more
TL;DR: Metabolomics is the global analysis of small molecule metabolites that like other -omics technologies can provide critical information about the cancer state that are otherwise not apparent as discussed by the authors, which can be further leveraged in the future to improve the management of patients with cancer.
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HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer
TL;DR: Rational therapeutic combinations seem most promising in the clinical exploitation of the intricate interplay of HIFs, angiogenesis, and metabolism in breast cancer cells and the tumor microenvironment.
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