Journal ArticleDOI
Fatty acid binding protein isoforms: structure and function
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TLDR
Which FABPs form biochemically defined or true isoforms versus FABP that form additional forms, operationally defined as isoforms, is critically evaluated.About:
This article is published in Chemistry and Physics of Lipids.The article was published on 1998-03-01. It has received 127 citations till now. The article focuses on the topics: Gene isoform.read more
Citations
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Sex-dependent impact of Scp-2/Scp-x gene ablation on hepatic phytol metabolism
TL;DR: The loss of Scp-2/Scp-x contributed to a sex-dependent hepatic accumulation of dietary phytol and BCFA, which accumulated increased proportion of saturated straight-chain fatty acids (LCFA) at the expense of unsaturated LCFA.
Journal ArticleDOI
Isolation and sequence characterization of mammary derived growth inhibitor gene of riverine buffalo (Bubalus bubalis).
TL;DR: Buffalo and cattle MDGI had 100% amino acid sequence similarity, which also shared three amino acid changes: 34 (Ala-Gly), 109 (Leu-Met), and 132 (Glu-Gln) as compared to other species, and MDGI is intermediate of FABP-heart and adipose.
Journal ArticleDOI
Insulin-like Growth Factor-I Induces FATP1 Expression in C2C12 Myotubes
Hye Jin Kim,Wonjun Lee +1 more
TL;DR: In conclusion, IGF-I induced rapid transcriptional modification of the FATP1 gene in C2C12 skeletal mus-cle cells and had modulating effects on fatty acid uptake proteins and oxidative proteins.
Book ChapterDOI
CHAPTER 11 – Genetic Influences on Blood Lipids and Cardiovascular Disease Risk
TL;DR: While several types of drug therapies are developed and shown to be highly effective in lowering serum LDL cholesterol values and CVD, the NCEP has emphasized that lifestyle modification should be the primary treatment for lowering cholesterol values, with drug therapies reserved for cases in which lifestyle modification is ineffective.
References
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Journal ArticleDOI
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling.
Nils J. Færgeman,Jens Knudsen +1 more
TL;DR: The observations that the ryanodine-senstitive Ca2+-release channel is regulated by long-chain acyl-CoA esters in the presence of a molar excess of acyl -CoA binding protein and that acetyl- coA carboxylase, the AMP kinase kinase and the Escherichia coli transcription factor FadR are affected by low nanomolar concentrations of Acyl- CoA indicate that long- chain acyl
Book ChapterDOI
Lipid-Binding Proteins: A Family of Fatty Acid and Retinoid Transport Proteins
Leonard J. Banaszak,Nathan S. Winter,Zhaohui Xu,David A. Bernlohr,S. W. Cowan,Alwyn T. Jones +5 more
TL;DR: This chapter focuses on the structural analyses and comparisons between members of a multigene family of hydrophobic ligand-binding proteins and provides a detailed comparison of intra- and extracellular lipid binding proteins with known crystal structures.
Journal ArticleDOI
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.
Leslie J. Baier,James C. Sacchettini,W. C. Knowler,Janina C. Eads,Giuseppe Paolisso,P. A. Tataranni,H Mochizuki,Peter H. Bennett,C Bogardus,Michal Prochazka +9 more
TL;DR: It is concluded that the threonine-containing protein may increase absorption and/or processing of dietary fatty acids by the intestine and thereby increase fat oxidation, which has been shown to reduce insulin action.
Journal ArticleDOI
Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB.
TL;DR: This study disagrees with earlier investigations in finding that equilibrium binding of FA to FABPs is a sensitive function of FA type and FABP tissue origin and that FA-FABP dissociation constants are submicromolar.
Journal ArticleDOI
Fatty acid binding protein. Isolation from rat liver, characterization, and immunochemical quantification.
R K Ockner,J A Manning,J P Kane +2 more
TL;DR: The abundance of FABP, its importance in the cytosolic binding of endogenous as well as exogenous fatty acids, and its demonstrated correlation with rates of hepatocyte fatty acid utilization provide additional evidence for its relationship to the cellular metabolism of long chain fatty acids.