Journal ArticleDOI
Fatty acid binding protein isoforms: structure and function
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TLDR
Which FABPs form biochemically defined or true isoforms versus FABP that form additional forms, operationally defined as isoforms, is critically evaluated.About:
This article is published in Chemistry and Physics of Lipids.The article was published on 1998-03-01. It has received 127 citations till now. The article focuses on the topics: Gene isoform.read more
Citations
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Journal ArticleDOI
Ablation of the liver fatty acid binding protein gene decreases fatty acyl CoA binding capacity and alters fatty acyl CoA pool distribution in mouse liver.
TL;DR: It is demonstrated for the first time that L-FABP is a physiologically significant contributor to determining liver cytosolic LCFA-CoA binding capacity,LCFA- CoA acyl chain distribution, and esterified fatty acid distribution.
Journal ArticleDOI
Microsomal fatty acyl-CoA transacylation and hydrolysis: fatty acyl-CoA species dependent modulation by liver fatty acyl-CoA binding proteins.
TL;DR: In this paper, a role for both L-FABP and ACBP in microsomal phosphatidic acid biosynthesis was established, which may explain the simultaneous presence of these proteins in cell types involved in fatty acid absorption and lipoprotein secretion.
Journal ArticleDOI
Regulation of the Liver Fatty Acid-binding Protein Gene by Hepatocyte Nuclear Factor 1α (HNF1α)
Journal ArticleDOI
Differential subcellular localization of two dopamine D2 receptor isoforms in transfected NG108‐15 cells
Yusuke Takeuchi,Kohji Fukunaga +1 more
TL;DR: Using a yeast two hybrid system with a mouse brain cDNA library and coimmunoprecipitation assay, it is found that heart‐type fatty acid binding protein (H‐FABP) interacts with D2LR but not with D1SR, a cytosolic protein involved in binding and transport of fatty acids.
Journal ArticleDOI
Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs.
TL;DR: It is shown that liver- (L-) FABP displays a high binding affinity for PPAR subtype selective drugs and may represent a mechanism for facilitating the activation of PPAR transcriptional activity via the direct channeling of ligands between the binding pocket of L-FABP and the PPARαLBD.
References
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Journal ArticleDOI
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling.
Nils J. Færgeman,Jens Knudsen +1 more
TL;DR: The observations that the ryanodine-senstitive Ca2+-release channel is regulated by long-chain acyl-CoA esters in the presence of a molar excess of acyl -CoA binding protein and that acetyl- coA carboxylase, the AMP kinase kinase and the Escherichia coli transcription factor FadR are affected by low nanomolar concentrations of Acyl- CoA indicate that long- chain acyl
Book ChapterDOI
Lipid-Binding Proteins: A Family of Fatty Acid and Retinoid Transport Proteins
Leonard J. Banaszak,Nathan S. Winter,Zhaohui Xu,David A. Bernlohr,S. W. Cowan,Alwyn T. Jones +5 more
TL;DR: This chapter focuses on the structural analyses and comparisons between members of a multigene family of hydrophobic ligand-binding proteins and provides a detailed comparison of intra- and extracellular lipid binding proteins with known crystal structures.
Journal ArticleDOI
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.
Leslie J. Baier,James C. Sacchettini,W. C. Knowler,Janina C. Eads,Giuseppe Paolisso,P. A. Tataranni,H Mochizuki,Peter H. Bennett,C Bogardus,Michal Prochazka +9 more
TL;DR: It is concluded that the threonine-containing protein may increase absorption and/or processing of dietary fatty acids by the intestine and thereby increase fat oxidation, which has been shown to reduce insulin action.
Journal ArticleDOI
Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB.
TL;DR: This study disagrees with earlier investigations in finding that equilibrium binding of FA to FABPs is a sensitive function of FA type and FABP tissue origin and that FA-FABP dissociation constants are submicromolar.
Journal ArticleDOI
Fatty acid binding protein. Isolation from rat liver, characterization, and immunochemical quantification.
R K Ockner,J A Manning,J P Kane +2 more
TL;DR: The abundance of FABP, its importance in the cytosolic binding of endogenous as well as exogenous fatty acids, and its demonstrated correlation with rates of hepatocyte fatty acid utilization provide additional evidence for its relationship to the cellular metabolism of long chain fatty acids.