Journal ArticleDOI
Fatty Acid Elongases in Mammals: Their Regulation and Roles in Metabolism
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TLDR
The regulation of the mammalian fatty acid elongases and their potential role in lipid metabolism are discussed and both the biochemical functions of the proteins, as well as their role in a more physiological context are considered.About:
This article is published in Progress in Lipid Research.The article was published on 2006-05-01. It has received 784 citations till now. The article focuses on the topics: Fatty acid elongation & Fatty acid.read more
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Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
Catherine Postic,Jean Girard +1 more
TL;DR: A review of recent advances in the field of nonalcoholic fatty liver disease discusses recent advances and suggests that modulating important enzymes in fatty acid synthesis in liver may be key for the treatment of NAFLD.
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The multifaceted roles of fatty acid synthesis in cancer
Florian Röhrig,Almut Schulze +1 more
TL;DR: This Review explores how different aspects of FA synthesis promote tumorigenesis and tumour progression and strategies to target this pathway have not yet translated into clinical practice.
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Fatty acid requirements in ontogeny of marine and freshwater fish
TL;DR: It is particularly important to note that the physiological requirements of the fish to prevent deficiency pathologies and produce optimal growth may not parallel the requirements for maintaining nutritional quality, so salmonids can be successfully cultured on vegetable oils devoid of long-chain n-3 PUFA but not without potentially compromising their health benefits to the human consumer.
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The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.
TL;DR: The first part of this review summarizes the current knowledge concerning elongases and desaturases and focuses on the insights gained from studies with these mice, as well as from investigations on cell cultures.
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Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Mika Hilvo,Carsten Denkert,Laura Lehtinen,Berit Maria Müller,Scarlet F. Brockmöller,Tuulikki Seppänen-Laakso,Jan Budczies,Elmar Bucher,Laxman Yetukuri,Sandra Castillo,Emilia Berg,Heli Nygren,Marko Sysi-Aho,Julian L. Griffin,Oliver Fiehn,Sibylle Loibl,Christiane Richter-Ehrenstein,Cornelia Radke,Tuulia Hyötyläinen,Olli Kallioniemi,Kristiina Iljin,Matej Orešič +21 more
TL;DR: Analyzing the global lipid profiles of breast cancer, integrating the results to protein expression, and validate the findings by functional experiments imply that phospholipids may have diagnostic potential as well as that modulation of their metabolism may provide therapeutic opportunities in breast cancer treatment.
References
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Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
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The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
TL;DR: This research was supported by grants from the National Institutes of Health (HL20948) and the Perot Family Foundation.
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Peroxisome proliferator-activated receptors: nuclear control of metabolism.
Béatrice Desvergne,Walter Wahli +1 more
TL;DR: This work has shown that direct expression of PPAR mRNAs in the absence of a specific carrier gene results in down-regulation in the activity of other PPARs, and these properties are consistent with those of a “spatially aggregating substance”.
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Nuclear receptors and lipid physiology: opening the X-files.
TL;DR: Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.
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An oxysterol signalling pathway mediated by the nuclear receptor LXRα
TL;DR: The results demonstrate the existence of a nuclear receptor signalling pathway for oxysterols and suggest that LXRα may be important as a sensor of cholesterol metabolites.