Journal ArticleDOI
Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice
Paola Losi,Enrica Briganti,Cesare Errico,Antonella Lisella,Elena Sanguinetti,Federica Chiellini,Giorgio Soldani +6 more
TLDR
The ability of the scaffold/GF-loaded NPs to promote wound healing in a diabetic mouse model suggests its potential use as a dressing in patients with diabetic foot ulcers.About:
This article is published in Acta Biomaterialia.The article was published on 2013-08-01. It has received 271 citations till now. The article focuses on the topics: Wound healing & Basic fibroblast growth factor.read more
Citations
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Journal ArticleDOI
Drug delivery systems and materials for wound healing applications.
Saghi Saghazadeh,Chiara Rinoldi,Maik Schot,Sara Saheb Kashaf,Fatemeh Sharifi,Elmira Jalilian,Kristo Nuutila,Giorgio Giatsidis,Pooria Mostafalu,Hossein Derakhshandeh,Kan Yue,Wojciech Swieszkowski,Adnan Memic,Ali Tamayol,Ali Khademhosseini +14 more
TL;DR: The pathophysiology of chronic wounds is discussed and then the materials used for engineering drug delivery systems are discussed, and the architecture of the delivery platform and its ability to modulate drug delivery are discussed.
Journal ArticleDOI
Therapeutic strategies for enhancing angiogenesis in wound healing.
TL;DR: This review surveys the creation of new treatments for healing cutaneous wounds through therapeutic angiogenesis and discusses the challenges and advancement that have been made in delivering biologic, pharmaceutical and cell-based therapies as enhancers of wound vascularity and healing.
Journal ArticleDOI
Novel biomaterial strategies for controlled growth factor delivery for biomedical applications
TL;DR: This review evaluates the latest techniques in direct immobilization and relevant biomaterials used for GF loading and release, including synthetic polymers, albumin, polysaccharides, lipids, mesoporous silica-based nanoparticles (NPs), and polymeric capsules and focuses on GF-encapsulated NPs in functionalized microporous scaffolds as a promising alternative.
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Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model.
TL;DR: This study is the first to show that exosomes derived from PRP (PRP-Exos) may exert the function of PRP, and provides evidence of the probable molecular mechanisms underlying the PRP effect on healing of chronic ulcers and describes a promising resource of growth factors from exosome without species restriction.
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Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies.
TL;DR: This review summarizes the current knowledge regarding the management and treatment of acute and chronic wounds, with a focus on re-epithelialization, offering some insights into novel future therapies.
References
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Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
TL;DR: Findings indicate that the "diabetes epidemic" will continue even if levels of obesity remain constant, and given the increasing prevalence of obesity, it is likely that these figures provide an underestimate of future diabetes prevalence.
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Pathophysiology of acute wound healing.
TL;DR: Although the desirable final result of coordinated healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon and results in a structurally and functionally satisfactory but not identical outcome.
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PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug.
TL;DR: It was found that an aqueous phase pH of 9.3, replacement of procaine hydrochloride with procaine dihydrate and the incorporation of PMMA-MA, lauric and caprylic acid into the formulation could enhance drug incorporation efficiency without the size, morphology and nanoparticle recovery being adversely influenced.
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Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors.
Naomi Trengove,Michael Stacey,Shawn P. Macauley,Neil T. Bennett,Jane S. Gibson,Frank Burslem,Gillian Murphy,Gregory S. Schultz +7 more
TL;DR: The elevated levels of matrix metalloproteinase activity decreased significantly as healing occurs in chronic leg ulcers, which parallels the processes observed in normally healing acute wounds and supports the case for the addition of protease inhibitors in chronic wounds in conjunction with any treatments using growth factors.
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Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes. IMPLICATIONS FOR NORMAL AND IMPAIRED WOUND HEALING
Stefan L. Frank,Griseldis Hübner,Georg Breier,Michael T. Longaker,David G. Greenhalgh,Sabine Werner +5 more
TL;DR: In normal mice, elevated VEGF mRNA levels during the period when granulation tissue formation occurs are found, suggesting that a defect in V EGF regulation might be associated with wound healing disorders.