Journal ArticleDOI
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
Jean E. Vance,Guergana Tasseva +1 more
TLDR
Targeted disruption of each PS synthase individually in mice demonstrated that neither enzyme is required for viability whereas elimination of both synthases was embryonic lethal, indicating that mammalian cells require a threshold amount of PS.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-03-01. It has received 479 citations till now. The article focuses on the topics: Phosphatidylethanolamine & Phosphatidylserine.read more
Citations
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Cargo recognition and trafficking in selective autophagy
TL;DR: The current view on how cargo selection and transport are achieved during selective autophagy is discussed, and molecular mechanisms that are congruent between autophagosomal membranes and vesicle trafficking pathways are pointed out.
Journal ArticleDOI
Lipids of mitochondria.
Susanne E. Horvath,Günther Daum +1 more
TL;DR: The mitochondrial lipid composition, the biosynthesis and the import of mitochondrial lipids as well as the regulation of these processes will be main issues of this review article.
Journal ArticleDOI
Selenium biochemistry and its role for human health
TL;DR: This review summarizes the most recent findings on the biochemistry of active selenium species in humans, and addresses the latest evidence on the link betweenselenium intake, selenoproteins functionality and beneficial health effects.
Journal ArticleDOI
Phospholipid synthesis and transport in mammalian cells.
TL;DR: In this paper, the authors summarized the pathways and subcellular sites of phospholipid synthesis in mammalian cells and showed that a single, unifying mechanism does not explain the inter-organelle transport of all PHs.
Journal ArticleDOI
Phosphatidylethanolamine deficiency in mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology
Guergana Tasseva,Helin Daniel Bai,Magdalena Davidescu,Alois Haromy,Evangelos D. Michelakis,Jean E. Vance +5 more
TL;DR: It is reported that moderate <30% depletion of mtPE alters mitochondrial morphology and function and impairs cell growth and imparts cell growth.
References
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Isolation and structure of a brain constituent that binds to the cannabinoid receptor
William A. Devane,Lumir Hanus,Aviva Breuer,Roger G. Pertwee,Lesley A. Stevenson,Graeme Griffin,Dan Gibson,Asher Mandelbaum,A. Etinger,Raphael Mechoulam +9 more
TL;DR: In this article, an arachidonylethanthanolamide (anandamide) was identified in a screen for endogenous ligands for the cannabinoid receptor and its structure was determined by mass spectrometry and nuclear magnetic resonance spectroscopy and confirmed by synthesis.
Journal Article
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.
Valerie A. Fadok,Dennis R. Voelker,Priscilla A. Campbell,J. John Cohen,D L Bratton,Peter M. Henson +5 more
TL;DR: The data suggest that macrophages specifically recognize phosphatidylserine that is exposed on the surface of lymphocytes during the development of apoptosis, and suggest that apoptotic lymphocytes lose membrane phospholipid asymmetry and expose phosphorus on the outer leaflet of the plasma membrane.
Journal ArticleDOI
Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca2+ Responses
Rosario Rizzuto,Paolo Pinton,Paolo Pinton,Walter A. Carrington,Walter A. Carrington,Frederic S. Fay,Frederic S. Fay,Kevin E. Fogarty,Kevin E. Fogarty,Lawrence M. Lifshitz,Lawrence M. Lifshitz,Richard A. Tuft,Richard A. Tuft,Tullio Pozzan,Tullio Pozzan +14 more
TL;DR: The spatial relation between mitochondria and endoplasmic reticulum in living HeLa cells was analyzed at high resolution in three dimensions with two differently colored, specifically targeted green fluorescent proteins to emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca2+ signaling.
Journal ArticleDOI
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
TL;DR: It is shown that mitofusin 2, a mitochondrial dynamin-related protein mutated in the inherited motor neuropathy Charcot–Marie–Tooth type IIa, is enriched at the ER–mitochondria interface, and that it tethers ER to mitochondria, a juxtaposition required for efficient mitochondrial Ca2+ uptake.
Journal ArticleDOI
ER Tubules Mark Sites of Mitochondrial Division
Jonathan R. Friedman,Laura L. Lackner,Matthew West,Jared R. DiBenedetto,Jodi Nunnari,Gia K. Voeltz +5 more
TL;DR: It was found that mitochondrial division occurred at positions where ER tubules contacted mitochondria and mediated constriction before Drp1 recruitment, suggesting that ERtubules may play an active role in defining the position of mitochondrial division sites.