Journal ArticleDOI
Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder
Vibe G. Frokjaer,Erik Lykke Mortensen,Finn Årup Nielsen,Finn Årup Nielsen,Steven Haugbøl,Lars H. Pinborg,Karen H. Adams,Claus Svarer,Steen G. Hasselbalch,S. Holm,Olaf B. Paulson,Gitte M. Knudsen +11 more
TLDR
The findings point to a neurobiological link between personality risk factors for affective disorder and the serotonergic transmitter system and identify the serotonin 2A receptor as a biomarker for vulnerability to affective disorders.About:
This article is published in Biological Psychiatry.The article was published on 2008-03-15. It has received 211 citations till now. The article focuses on the topics: Neuroticism & Revised NEO Personality Inventory.read more
Citations
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Journal ArticleDOI
Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268
Journal ArticleDOI
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial
Stephen Ross,Anthony P. Bossis,Jeffrey Guss,Gabrielle Agin-Liebes,Tara C. Malone,Barry H. Cohen,Sarah E. Mennenga,Alexander B. Belser,Krystallia Kalliontzi,James Babb,Zhe Su,Patricia Corby,Brian L. Schmidt +12 more
TL;DR: Psilocybin was associated with enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress, sustained benefits in existential distress and quality of life, as well as improved attitudes towards death.
Journal ArticleDOI
The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs
Robin L. Carhart-Harris,Robert Leech,Peter J. Hellyer,Murray Shanahan,Amanda Feilding,Enzo Tagliazucchi,Dante R. Chialvo,David J. Nutt +7 more
TL;DR: It is argued that the defining feature of “primary states” is elevated entropy in certain aspects of brain function, such as the repertoire of functional connectivity motifs that form and fragment across time, and that this entropy suppression furnishes normal waking consciousness with a constrained quality and associated metacognitive functions, including reality-testing and self-awareness.
Journal ArticleDOI
Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study
Michael P. Bogenschutz,Alyssa A. Forcehimes,Jessica Pommy,Claire E. Wilcox,Paulo Cesar Ribeiro Barbosa,Rick J. Strassman +5 more
TL;DR: A single-group proof-of-concept study to quantify acute effects of psilocybin in alcohol-dependent participants and to provide preliminary outcome and safety data, providing a strong rationale for controlled trials with larger samples to investigate efficacy and mechanisms.
Journal ArticleDOI
The neurobiology of psychedelic drugs: implications for the treatment of mood disorders
TL;DR: Recent behavioural and neuroimaging data show that psychedelics modulate neural circuits that have been implicated in mood and affective disorders, and can reduce the clinical symptoms of these disorders.
References
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Journal ArticleDOI
Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain
Nathalie Tzourio-Mazoyer,B. Landeau,D. Papathanassiou,Fabrice Crivello,Octave Etard,Nicolas Delcroix,Bernard Mazoyer,Marc Joliot +7 more
TL;DR: An anatomical parcellation of the spatially normalized single-subject high-resolution T1 volume provided by the Montreal Neurological Institute was performed and it is believed that this tool is an improvement for the macroscopical labeling of activated area compared to labeling assessed using the Talairach atlas brain.
Journal ArticleDOI
Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268
Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
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Personality development: stability and change.
TL;DR: This review examines research about the structure of personality in childhood and in adulthood, with special attention to possible developmental changes in the lower-order components of broad traits.
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