Journal ArticleDOI
Functional Synthetic Probes for Selective Targeting and Multi-analyte Detection and Imaging
Yongkang Yue,Fangjun Huo,Fangqin Cheng,Xijing Zhu,Tendai Mafireyi,Robert M. Strongin,Caixia Yin +6 more
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TLDR
This review focuses on recent innovations in probe design, detection mechanisms and the investigation of biological processes and the ongoing development of fluorescent probes to enable deeper insight into the physiology of bioactive analytes.Abstract:
In contrast to the classical design of a probe with one binding site to target one specific analyte, probes with multiple interaction sites or, alternatively, with single sites promoting tandem reactions to target one or multiple analytes, have been developed. They have been used in addressing the inherent challenges of selective targeting in the presence of structurally similar compounds and in complex matrices, as well as the visualization of the in vivo interaction or crosstalk between the analytes. Examples of analytes include reactive sulfur species, reactive oxygen species, nucleotides and enzymes. This review focuses on recent innovations in probe design, detection mechanisms and the investigation of biological processes. The vision is to promote the ongoing development of fluorescent probes to enable deeper insight into the physiology of bioactive analytes.read more
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Fluorescent small organic probes for biosensing
TL;DR: Sensing mechanisms including Förster resonance energy transfer (FRET), intramolecular charge transfer (ICT), photoinduced electron transfer (PeT), excited state intramolescular proton transfer (ESIPT), aggregation induced emission (AIE) and multiple modality fluorescence approaches including dual/triple sensing mechanisms (DSM or TSM) are highlighted.
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Fluorescence imaging of pathophysiological microenvironments
TL;DR: In this paper, the state-of-the-art progress of fluorescent probes for visualizing pathophysiological microenvironments (viscosity, pH, and polarity), since 2016, as well as the future perspectives in this challenging field.
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BODIPY-Based Fluorescent Probes for Biothiols
TL;DR: This review systematically summarized the development of the fluorescent probes based on BODIPYs for detection of biothiols, preferable detection of individual biothiolas, as well as simultaneous discrimination among Cys, Hcy and GSH.
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Recent progress in fluorescent probes for detection of carbonyl species: Formaldehyde, carbon monoxide and phosgene
TL;DR: In this paper, the most significant developments in fluorescent probes for the detection of the carbonyl species formaldehyde, carbon monoxide and phosgene in recent years, with a special emphasis on their mechanisms and applications.
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Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook.
Haidong Li,Heejeong Kim,Feng Xu,Jingjing Han,Qichao Yao,Jingyun Wang,Kanyi Pu,Xiaojun Peng,Ju-Yoon Yoon +8 more
TL;DR: This review describes the brief history of the discovery of hemicyanine dyes, synthetic approaches, and design strategies for activity-based functional fluorescent probes and identifies many selected he micyanine-based probes that can detect ions, small biomolecules, overexpressed enzymes and diagnostic reagents for diseases.
References
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BODIPY dyes and their derivatives: syntheses and spectroscopic properties.
Aurore Loudet,Kevin Burgess +1 more
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Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Sudha Seshadri,Alexa S. Beiser,Jacob Selhub,Paul F. Jacques,Irwin H. Rosenberg,Ralph B. D'Agostino,Peter W.F. Wilson,Philip A. Wolf +7 more
TL;DR: Dementia developed in 111 subjects, including 83 given a diagnosis of Alzheimer's disease, over a median follow-up period of eight years, and plasma levels of folate and vitamins B12 and B6 increased.
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Fluorescent Sensors for Measuring Metal Ions in Living Systems
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Creating new fluorescent probes for cell biology.
TL;DR: Advances include the continued development of 'passive' markers for the measurement of biomolecule expression and localization in live cells, and 'active' indicators for monitoring more complex cellular processes such as small-molecule-messenger dynamics, enzyme activation and protein–protein interactions.
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New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
TL;DR: Although MRI, US, and x-ray CT are often listed as molecular imaging modalities, in truth, radionuclide and optical imaging are the most practical modalities for molecular imaging, because of their sensitivity and the specificity for target detection.