Journal ArticleDOI
γ-Tocotrienol induced cell cycle arrest and apoptosis via activating the Bax-mediated mitochondrial and AMPK signaling pathways in 3T3-L1 adipocytes.
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TLDR
The potent anti-proliferative and anti-adipogenic effects of γT3 on 3T3-L1 adipocytes could be through the Bax-mediated mitochondrial and AMPK signaling pathways.About:
This article is published in Food and Chemical Toxicology.The article was published on 2013-09-01. It has received 20 citations till now. The article focuses on the topics: AMPK & Mitochondrion.read more
Citations
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Journal ArticleDOI
Structural analysis and anti-obesity effect of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.).
TL;DR: It is suggested that JS-MP-1 itself or a crude aqueous Oddi extract containing this polysaccharide can be used as functional ingredient of health-beneficial food supplements for the treatment or prevention of obesity disorders.
Journal ArticleDOI
Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin resistance by inhibiting adipose inflammation and M1 macrophage recruitment
TL;DR: It is demonstrated that γT3 ameliorates HF diet-mediated obesity and insulin resistance by inhibiting systemic and adipose inflammation, as well as ATM recruitment.
Journal ArticleDOI
Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes.
TL;DR: It is demonstrated, for the first time, that γT3 inhibits the NLRP3 inflammasome thereby delaying the progression of type 2 diabetes.
Journal ArticleDOI
Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence
Sok Kuan Wong,Yusof Kamisah,Norazlina Mohamed,Norliza Muhammad,Norliana Masbah,Nur Azlina Mohd Fahami,Isa Naina Mohamed,Ahmad Nazun Shuid,Qodriyah Mohd Saad,Azman Abdullah,Nur-Vaizura Mohamad,Nurul 'Izzah Ibrahim,Kok-Lun Pang,Yoke Yue Chow,Benjamin Ka Seng Thong,Shaanthana Subramaniam,Chin Yi Chan,Soelaiman Ima-Nirwana,Kok-Yong Chin +18 more
TL;DR: The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders.
Journal ArticleDOI
The Role of Tocotrienol in Protecting Against Metabolic Diseases.
Kok-Lun Pang,Kok-Yong Chin +1 more
TL;DR: Tocotrienol, as a functional food component with anti-inflammatory, antioxidant, and cell signaling-mediating effects, may be a potential agent to complement the current management of obesity and diabetes.
References
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Journal ArticleDOI
Mammalian MAP kinase signalling cascades
Lufen Chang,Michael Karin +1 more
TL;DR: Recent studies have begun to shed light on the physiological functions of MAPK cascades in the control of gene expression, cell proliferation and programmed cell death.
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Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
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A central role for JNK in obesity and insulin resistance
Jiro Hirosumi,Gurol Tuncman,Lufen Chang,Cem Z. Görgün,K. Teoman Uysal,Kazuhisa Maeda,Michael Karin,Gökhan S. Hotamisligil +7 more
TL;DR: It is shown that JNK activity is abnormally elevated in obesity and an absence of JNK1 results in decreased adiposity, significantly improved insulin sensitivity and enhanced insulin receptor signalling capacity in two different models of mouse obesity.
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Apoptosis: a link between cancer genetics and chemotherapy.
TL;DR: Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.
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AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
TL;DR: Although it may have evolved to respond to metabolic stress at the cellular level, hormones and cytokines such as insulin, leptin, and adiponectin can interact with the system, and it now appears to play a key role in maintaining energy balance at the whole body level.