Generating tissue topology through remodeling of cell-cell adhesions.
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TLDR
This review discusses work investigating the formation of folds, tubes, and branched networks with an emphasis on known or possible roles for cell-cell adhesion, and examines recently developed tools that could be adapted to manipulate cell- cell adhesion in engineered tissues.About:
This article is published in Experimental Cell Research.The article was published on 2017-09-01 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Role of cell adhesions in neural development.read more
Citations
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Journal ArticleDOI
The extracellular matrix in development.
TL;DR: Current understanding of how the extracellular matrix helps guide developing tissues by influencing cell adhesion, migration, shape and differentiation is discussed, emphasizing the biophysical cues it provides.
Journal ArticleDOI
Scutoids are a geometrical solution to three-dimensional packing of epithelia.
Pedro Gómez-Gálvez,Pablo Vicente-Munuera,Antonio Tagua,Cristina Forja,Ana M. Castro,Marta Letrán,Andrea Valencia-Expósito,Clara I. Grima,Marina Bermúdez-Gallardo,Óscar Serrano-Pérez-Higueras,Florencia Cavodeassi,Florencia Cavodeassi,Sol Sotillos,María D. Martín-Bermudo,Alberto Márquez,Javier Buceta,Luis M. Escudero +16 more
TL;DR: It is shown by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis and predicted that cells adopt a geometrical shape they call “scutoid”, resulting in different apical and basal neighbours, and confirmed the presence of scutoids in curved tissues.
Journal ArticleDOI
De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects.
Andrea Accogli,Sara Calabretta,Judith St-Onge,Nassima Boudrahem-Addour,Alexandre Dionne-Laporte,Pascal Joset,Silvia Azzarello-Burri,Anita Rauch,Joel B. Krier,Elizabeth L. Fieg,Juan C Pallais,Allyn McConkie-Rosell,Marie T. McDonald,Sharon F. Freedman,Jean-Baptiste Rivière,Joël Lafond-Lapalme,Brittany N. Simpson,Robert J. Hopkin,Aurélien Trimouille,Julien Van-Gils,Amber Begtrup,Kirsty McWalter,Heron Delphine,Boris Keren,David Geneviève,Emanuela Argilli,Elliott H. Sherr,Mariasavina Severino,Guy A. Rouleau,Patricia T. Yam,Frédéric Charron,Myriam Srour +31 more
TL;DR: It is shown that cells expressing variants in the EC4-EC5 domains have a defect in cell-cell adhesion; this defect includes impaired binding in trans with N-cadherin-WT expressed on apposing cells.
Journal ArticleDOI
Secret handshakes: cell-cell interactions and cellular mimics.
Daniel J. Cohen,W. James Nelson +1 more
TL;DR: A review of recent developments in cell-cell junctions can be found in this article, providing both historical context and a discussion of some topical challenges and opportunities for the future, as well as a discussion about the potential of cell-mimetic interfaces.
Journal ArticleDOI
Cell shape changes during larval body plan development in Clytia hemisphaerica.
TL;DR: It is proposed that cell ingression in Clytia not only provides the endoderm, but generates internal forces that shape the embryo in the course of gastrulation.
References
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Directed actin polymerization is the driving force for epithelial cell-cell adhesion.
TL;DR: A dynamic mechanism for intercellular adhesion is unveiled involving calcium-activated filopodia penetration and VASP/Mena-dependent actin reorganization/polymerization.
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Pulsed contractions of an actin–myosin network drive apical constriction
TL;DR: A new model for apical constriction is suggested in which a cortical actin–myosin cytoskeleton functions as a developmentally controlled subcellular ratchet to reduce apical area incrementally.
Journal ArticleDOI
Designer matrices for intestinal stem cell and organoid culture
Nikolce Gjorevski,Norman Sachs,Andrea Manfrin,Sonja Giger,Maiia E. Bragina,Paloma Ordóñez-Morán,Hans Clevers,Matthias P. Lutolf +7 more
TL;DR: Modular synthetic hydrogel networks are used to define the key extracellular matrix parameters that govern intestinal stem cell (ISC) expansion and organoid formation, and show that separate stages of the process require different mechanical environments and ECM components.
Journal ArticleDOI
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
Lars Jakobsson,Claudio A. Franco,Katie Bentley,Russell T. Collins,Bas Ponsioen,Irene M. Aspalter,Ian Rosewell,Marta Busse,Gavin Thurston,Alexander Medvinsky,Stefan Schulte-Merker,Holger Gerhardt,Holger Gerhardt +12 more
TL;DR: In this paper, the authors used computational modelling and genetic mosaic sprouting assays in vitro and in vivo to investigate the regulation and dynamics of endothelial cells during tip cell selection.
Journal ArticleDOI
Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled.
Tadao Usui,Yasuyuki Shima,Yuko Shimada,Shinji Hirano,Robert W. Burgess,Thomas Schwarz,Masatoshi Takeichi,Tadashi Uemura,Tadashi Uemura +8 more
TL;DR: It is suggested that cells acquire the P-D polarity by way of the Fz-dependent boundary localization of Fmi, which appears to be driven by an imbalance of the activity of Frizzled across the proximal/distal cell boundary.
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Embryonic cell-cell adhesion: a key player in collective neural crest migration
Elias H. Barriga,Roberto Mayor +1 more