Journal ArticleDOI
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.
Shuen-Iu Hung,Wen-Hung Chung,Wen-Hung Chung,Shiou-Hwa Jee,Wen Chieh Chen,Yun Ting Chang,Woan Ruoh Lee,Shu Ling Hu,Meng Tse Wu,Gwo Shing Chen,Tak Wah Wong,Pa Fan Hsiao,Wei Hsuan Chen,Han-Yu Shih,Wu Hsiang Fang,Chun Yu Wei,Yi Hui Lou,Yau Li Huang,Juei-Jueng Lin,Yuan-Tsong Chen +19 more
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TLDR
The data suggest that HLA-B*1502 could contribute to the pathogenesis ofCBZ-SJS/TEN, and that genetic susceptibility to CBZ-induced cADRs is phenotype-specific.Abstract:
The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We reported that SJS/TEN caused by CBZ is strongly associatread more
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HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
Mark McCormack,Ana Alfirevic,Stephane Bourgeois,John J. Farrell,Dalia Kasperavičiūtė,Mary Carrington,Graeme J. Sills,Tony Marson,Xiaoming Jia,Paul I.W. de Bakker,Krishna Chinthapalli,Mariam Molokhia,Marvin Johnson,Gerard D. O'Connor,Elijah Chaila,Saud Alhusaini,Kevin V. Shianna,Rodney A. Radtke,Erin L. Heinzen,Nicole M. Walley,Massimo Pandolfo,Werner J. Pichler,B. Kevin Park,Chantal Depondt,Sanjay M. Sisodiya,David Goldstein,Panos Deloukas,Norman Delanty,Norman Delanty,Gianpiero L. Cavalleri,Munir Pirmohamed +30 more
TL;DR: The presence of the HLA-A*3101 allele was associated with carbamazepine-induced hypersensitivity reactions among subjects of Northern European ancestry.
Journal ArticleDOI
International Consensus on drug allergy.
Pascal Demoly,N. F. Adkinson,Knut Brockow,Mariana Castells,Anca-Mirela Chiriac,Paul A. Greenberger,David A. Khan,David M. Lang,Hae-Sim Park,Werner J. Pichler,Mario Sánchez-Borges,Tetsuo Shiohara,Bernard Yu-Hor Thong +12 more
TL;DR: The purpose of this document is to highlight the key messages that are common to many of the existing guidelines, while critically reviewing and commenting on any differences and deficiencies of evidence, thus providing a comprehensive reference document for the diagnosis and management of DHRs.
Journal ArticleDOI
Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan
Pei Chen,Juei-Jueng Lin,Chin-Song Lu,Chin-Song Lu,Cheung-Ter Ong,Peiyuan F. Hsieh,Chih-Chao Yang,Chih-Ta Tai,Shey-Lin Wu,Cheng-Hsien Lu,Yung-Chu Hsu,Hsiang-Yu Yu,Hsiang-Yu Yu,Long-Sun Ro,Long-Sun Ro,Chung-Ta Lu,Chung-Ta Lu,Chun-Che Chu,Chun-Che Chu,Jing-Jane Tsai,Yu-Hsiang Su,Sheng-Hsing Lan,Sheng-Feng Sung,Shu-Yi Lin,Hui-Ping Chuang,Li-Chen Huang,Ying Ju Chen,Pei-Joung Tsai,Hung-Ting Liao,Yu-Hsuan Lin,Chien-Hsiun Chen,Wen-Hung Chung,Wen-Hung Chung,Shuen-Iu Hung,Jer-Yuarn Wu,Chi-Feng Chang,Luke I Chen,Yuan-Tsong Chen,Yuan-Tsong Chen,Chen-Yang Shen,Chen-Yang Shen +40 more
TL;DR: The identification of subjects carrying the HLA-B*1502 allele and the avoidance of carbamazepine therapy in these subjects was strongly associated with a decrease in the incidence of carbazepine-induced SJS-TEN.
Journal ArticleDOI
A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs.
Christine Lonjou,Nicolas Borot,Peggy Sekula,Neil Ledger,Laure Thomas,Sima Halevy,Luigi Naldi,Jan-Nico Bouwes-Bavinck,Alexis Sidoroff,Claudia de Toma,Martin Schumacher,Jean-Claude Roujeau,Alain Hovnanian,Maja Mockenhaupt +13 more
TL;DR: This study shows that even when HLA-B alleles behave as strong risk factors, as for allopurinol, they are neither sufficient nor necessary to explain the disease.
Journal ArticleDOI
ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson Syndrome and toxic epidermal necrolysis: comparison with case-control analysis.
B. Sassolas,C Haddad,Maja Mockenhaupt,A. Dunant,A. Dunant,Yvonne Liss,K Bork,U F Haustein,D Vieluf,Jean-Claude Roujeau,H Le Louet +10 more
TL;DR: Being more sensitive than a general method, ALDEN, which correlates well with case–control analysis results, can be considered a reference tool in SJS/TEN.
References
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Journal ArticleDOI
Medical genetics: A marker for Stevens-Johnson syndrome
Wen-Hung Chung,Shuen-Iu Hung,Hong-Shang Hong,Mo-Song Hsih,Li-Cheng Yang,Hsin-Chun Ho,Jer-Yuarn Wu,Jer-Yuarn Wu,Yuan-Tsong Chen,Yuan-Tsong Chen +9 more
TL;DR: This paper showed that there is a strong association in Han Chinese between the human leukocyte antigen HLA-B*1502 and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures.
Journal ArticleDOI
Severe Adverse Cutaneous Reactions to Drugs
TL;DR: Adverse cutaneous reactions to drugs are frequent, affecting 2 to 3 percent of hospitalized patients, and prompt withdrawal of the offending drug is often the most important action to minimize morbidity.
Journal ArticleDOI
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
Simon Mallal,Simon Mallal,David Nolan,C.S. Witt,C.S. Witt,G. Masel,G. Masel,Annalise M Martin,Corey Moore,D.C. Sayer,D.C. Sayer,A. Castley,Cyril D. S. Mamotte,Cyril D. S. Mamotte,D. Maxwell,Ian James,Frank T. Christiansen,Frank T. Christiansen +17 more
TL;DR: In this population of HIV-1-positive individuals, withholding abacavir in those with HLA-B*5701, H LA-DR7, and Hla-DQ3 should reduce the prevalence of hypersensitivity from 9% to 2.5% without inappropriately denying abacvir to any patient.
Journal ArticleDOI
Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis
Jean-Claude Roujeau,Judith P. Kelly,Luigi Naldi,B. Rzany,Robert S. Stern,Theresa E. Anderson,Ariane Auquier,Sylvie Bastuji-Garin,Osvaldo Correia,F. Locati +9 more
TL;DR: Risks were increased for trimethoprim–sulfamethoxazole and other sulfonamide antibiotics, chlormezanone, quinolones, and aminopenicillins among drugs usually used for short periods.
Journal ArticleDOI
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
Shuen Lu Hung,Wen-Hung Chung,Wen-Hung Chung,Wen-Hung Chung,Lieh Bang Liou,Chen Chung Chu,Marie Lin,Hsien Ping Huang,Yen Ling Lin,Joung Liang Lan,Li Cheng Yang,Hong Shang Hong,Ming Jing Chen,Ping Chin Lai,Mai Szu Wu,Chia-Yu Chu,Chia-Yu Chu,Kuo Hsien Wang,Chien-Hsiun Chen,Cathy S.J. Fann,Jer-Yuarn Wu,Jer-Yuarn Wu,Yuan-Tsong Chen,Yuan-Tsong Chen +23 more
TL;DR: The results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese, and in particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition.
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HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
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HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
Mark McCormack,Ana Alfirevic,Stephane Bourgeois,John J. Farrell,Dalia Kasperavičiūtė,Mary Carrington,Graeme J. Sills,Tony Marson,Xiaoming Jia,Paul I.W. de Bakker,Krishna Chinthapalli,Mariam Molokhia,Marvin Johnson,Gerard D. O'Connor,Elijah Chaila,Saud Alhusaini,Kevin V. Shianna,Rodney A. Radtke,Erin L. Heinzen,Nicole M. Walley,Massimo Pandolfo,Werner J. Pichler,B. Kevin Park,Chantal Depondt,Sanjay M. Sisodiya,David Goldstein,Panos Deloukas,Norman Delanty,Norman Delanty,Gianpiero L. Cavalleri,Munir Pirmohamed +30 more