Genome-Wide Analysis of Protein-Coding Variants in Leprosy.
Hong Liu,Zhenzhen Wang,Zhenzhen Wang,Yi Li,Gongqi Yu,Xi'an Fu,Xi'an Fu,Chuan Wang,Wenting Liu,Yongxiang Yu,Yongxiang Yu,Fangfang Bao,Astrid Irwanto,Jian Liu,Jian Liu,Tongsheng Chu,Tongsheng Chu,Anand Kumar Andiappan,Sebastian Maurer-Stroh,Sebastian Maurer-Stroh,Vachiranee Limviphuvadh,Honglei Wang,Honglei Wang,Zihao Mi,Yonghu Sun,Lele Sun,Ling Wang,Chaolong Wang,Jiabao You,Jiabao You,Jinghui Li,Jinghui Li,Jia Nee Foo,Herty Liany,Wee Yang Meah,Guiye Niu,Guiye Niu,Zhenhua Yue,Zhenhua Yue,Qing Zhao,Qing Zhao,Na Wang,Na Wang,Meiwen Yu,Wenjun Yu,Wenjun Yu,Xiujun Cheng,Xiujun Cheng,Chiea Chuen Khor,Kar Seng Sim,Tin Aung,Ningli Wang,De Yun Wang,Li Shi,Yong Ning,Zhongyi Zheng,Rongde Yang,Jinlan Li,Jun Yang,Liangbin Yan,Jianping Shen,Guocheng Zhang,Shumin Chen,Shumin Chen,Jianjun Liu,Furen Zhang +65 more
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TLDR
A three-stage genome-wide association study of protein-coding variants in Han Chinese showed involvement of skin barrier and endocytosis/phagocyTosis/autophagy, in addition to known innate and adaptive immunity, in the pathogenesis of leprosy, highlighting the merits ofprotein-c coding variant studies for complex diseases.About:
This article is published in Journal of Investigative Dermatology.The article was published on 2017-12-01 and is currently open access. It has received 33 citations till now. The article focuses on the topics: Genome-wide association study.read more
Citations
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A new hypothesis for Parkinson's disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics.
TL;DR: A novel hypothesis for a more comprehensive working model where autophagy is controlled by upstream pathways, such as GTPase-p38, that have been so far underexplored in this context is proposed.
Journal ArticleDOI
Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese
Dong Wang,Dong Wang,Yu Fan,Yu Fan,Mahadev Malhi,Mahadev Malhi,Rui Bi,Rui Bi,Yong Wu,Yong Wu,Min Xu,Min Xu,Xiu-Feng Yu,Heng Long,Yu-Ye Li,Deng-Feng Zhang,Deng-Feng Zhang,Yong-Gang Yao +17 more
TL;DR: Using the population attributable fraction, it is shown that HIF1A and LACC1 are the major genes with missense variants contributing to leprosy risk in the authors' study groups.
Journal ArticleDOI
Advances in the Immunology and Genetics of Leprosy
Zihao Mi,Hong Liu,Furen Zhang +2 more
TL;DR: In this context, advances in both the immunology and genetics of leprosy are summarized and the perspective of the combination of immunological and genetic approaches in studying the molecular mechanism ofLeprosy pathogenesis is discussed.
Journal ArticleDOI
Genetics of leprosy: today and beyond
TL;DR: The overlap of the genetic control in leprosy with Parkinson’s disease and inflammatory bowel disease is discussed and the findings make leproSy a good model for the study of complex immune-mediated diseases.
Journal ArticleDOI
Human genetics of mycobacterial disease
TL;DR: Some of the findings achieved by genome-wide linkage, association and transcriptome analyses in TB disease and leprosy and the recent genetic findings for BU susceptibility are summarized.
References
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