Genome-wide analysis of protein disorder in Arabidopsis thaliana: implications for plant environmental adaptation.
Natalia Pietrosemoli,Natalia Pietrosemoli,Juan Antonio Garcia-Martin,Roberto Solano,Florencio Pazos +4 more
TLDR
Because plants cannot escape from environmental conditions as animals do, they use disorder as a simple and fast mechanism, independent of transcriptional control, for introducing versatility in the interaction networks underlying these biological processes so that they can quickly adapt and respond to challenging environmental conditions.Abstract:
Intrinsically Disordered Proteins/Regions (IDPs/IDRs) are currently recognized as a widespread phenomenon having key cellular functions. Still, many aspects of the function of these proteins need to be unveiled. IDPs conformational flexibility allows them to recognize and interact with multiple partners, and confers them larger interaction surfaces that may increase interaction speed. For this reason, molecular interactions mediated by IDPs/IDRs are particularly abundant in certain types of protein interactions, such as those of signaling and cell cycle control. We present the first large-scale study of IDPs in Arabidopsis thaliana, the most widely used model organism in plant biology, in order to get insight into the biological roles of these proteins in plants. The work includes a comparative analysis with the human proteome to highlight the differential use of disorder in both species. Results show that while human proteins are in general more disordered, certain functional classes, mainly related to environmental response, are significantly more enriched in disorder in Arabidopsis. We propose that because plants cannot escape from environmental conditions as animals do, they use disorder as a simple and fast mechanism, independent of transcriptional control, for introducing versatility in the interaction networks underlying these biological processes so that they can quickly adapt and respond to challenging environmental conditions.read more
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Book ChapterDOI
Intrinsically Disordered Proteins
TL;DR: This Sprenger Briefs volume is dedicated to IDPs and IDPRs and an attempt is made to compress a massive amount of knowledge and into a digest that aims to be of use to those wishing a fast entry into this promising field of structural biology.
Journal ArticleDOI
Redundancy and specificity in jasmonate signalling
TL;DR: The molecular modularity that is thereby created enables a single bioactive hormone to specifically modulate multiple JA-outputs in response to different environmental and developmental cues.
Journal ArticleDOI
Regulatory network of NAC transcription factors in leaf senescence.
TL;DR: These studies clearly demonstrated the highly complex characteristics of NAC regulatory networks, which are dynamically regulated temporally and spatially and effectively integrate multiple developmental and environmental signals.
Journal ArticleDOI
Auxin Response Factors: output control in auxin biology.
TL;DR: In the two decades following the identification of the first ARF in Arabidopsis, much has been learnt about how these transcription factors act, and how they generate unique auxin responses.
Journal ArticleDOI
Perspective on Alternative Splicing and Proteome Complexity in Plants.
TL;DR: This work proposes that chromatin state-dependent AS engenders short/long-term stress memory to mediate reproducible transcriptional response in the future and suggests that plants may make fewer proteins with disordered domains via AS to diversify substrate specificity and maintain sufficient regulatory capacity.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Journal ArticleDOI
REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
TL;DR: REVIGO is a Web server that summarizes long, unintelligible lists of GO terms by finding a representative subset of the terms using a simple clustering algorithm that relies on semantic similarity measures.
Journal ArticleDOI
Intrinsically unstructured proteins and their functions.
H. Jane Dyson,Peter E. Wright +1 more
TL;DR: Many gene sequences in eukaryotic genomes encode entire proteins or large segments of proteins that lack a well-structured three-dimensional fold, whereas others constitute flexible linkers that have a role in the assembly of macromolecular arrays.
Journal ArticleDOI
The Gene Ontology (GO) database and informatics resource.
Midori A. Harris,Jennifer I. Clark,Ireland A,Jane Lomax,Michael Ashburner,Michael Ashburner,R. Foulger,R. Foulger,Karen Eilbeck,Karen Eilbeck,Suzanna E. Lewis,Suzanna E. Lewis,B. Marshall,B. Marshall,Christopher J. Mungall,Christopher J. Mungall,J. Richter,J. Richter,Gerald M. Rubin,Gerald M. Rubin,Judith A. Blake,Carol J. Bult,Dolan M,Drabkin H,Janan T. Eppig,Hill Dp,L. Ni,Ringwald M,Rama Balakrishnan,Rama Balakrishnan,J. M. Cherry,J. M. Cherry,Karen R. Christie,Karen R. Christie,Maria C. Costanzo,Maria C. Costanzo,Selina S. Dwight,Selina S. Dwight,Stacia R. Engel,Stacia R. Engel,Dianna G. Fisk,Dianna G. Fisk,Jodi E. Hirschman,Jodi E. Hirschman,Eurie L. Hong,Eurie L. Hong,Robert S. Nash,Robert S. Nash,Anand Sethuraman,Anand Sethuraman,Chandra L. Theesfeld,Chandra L. Theesfeld,David Botstein,David Botstein,Kara Dolinski,Kara Dolinski,Becket Feierbach,Becket Feierbach,Tanya Z. Berardini,Tanya Z. Berardini,S. Mundodi,S. Mundodi,Seung Y. Rhee,Seung Y. Rhee,Rolf Apweiler,Daniel Barrell,Camon E,E. Dimmer,Lee,Rex L. Chisholm,Pascale Gaudet,Pascale Gaudet,Warren A. Kibbe,Warren A. Kibbe,Ranjana Kishore,Ranjana Kishore,Erich M. Schwarz,Erich M. Schwarz,Paul W. Sternberg,Paul W. Sternberg,M. Gwinn,Hannick L,Wortman J,Matthew Berriman,Matthew Berriman,Wood,Wood,de la Cruz N,de la Cruz N,Peter J. Tonellato,Peter J. Tonellato,Pankaj Jaiswal,Pankaj Jaiswal,Seigfried T,Seigfried T,White R,White R +96 more
TL;DR: The Gene Ontology (GO) project as discussed by the authors provides structured, controlled vocabularies and classifications that cover several domains of molecular and cellular biology and are freely available for community use in the annotation of genes, gene products and sequences.