Journal ArticleDOI
Genotoxicity and biocompatibility of superparamagnetic iron oxide nanoparticles: Influence of surface modification on biodistribution, retention, DNA damage and oxidative stress.
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SPION-DMAB can be further studied for oral drug delivery to the brain and imaging of cerebral tissue without any functional ligand or external magnetic field.About:
This article is published in Food and Chemical Toxicology.The article was published on 2020-02-01. It has received 33 citations till now. The article focuses on the topics: Nanocapsules.read more
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Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review
Yvonne Kohl,Elise Rundén-Pran,Espen Mariussen,Michelle Hesler,Naouale El Yamani,Eleonora Longhin,Maria Dusinska +6 more
TL;DR: A literature review of in vitro studies published from 2000–2020 (August) dedicated to the genotoxicity of nanomaterials (NMs) in new models is performed with a focus on advances in miniaturization, organ-on-a-chip and high throughput methods.
Journal ArticleDOI
Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era.
TL;DR: The aim of this review is to provide a general outline of magnetic hyperthermia, focusing on iron oxide nanoparticles and their interactions with magnetic fields, as well as on new strategies to efficiently deliver them to the target site, and on recent in vitro and in vivo studies proposing possible cell death pathways activated by the treatment.
Journal ArticleDOI
Reactive Oxygen Species-Based Nanomaterials for Cancer Therapy.
Yingbo Li,Yang Jie,Xilin Sun +2 more
TL;DR: In this article, a review of reactive oxygen species (ROS)-based nanomaterials for oncological applications is presented, highlighting their biomedical applications in cancer therapy as drug delivery systems (DDSs) or in combination with chemodynamic therapy, photodynamic therapy (PDT), or sonodynamic therapy(SDT).
Journal ArticleDOI
Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges
TL;DR: A systematic review of the use of superparamagnetic iron oxide nanoparticles (SPIONs) for targeted delivery of drugs into the ear and the central nervous system is presented in this article.
Journal ArticleDOI
Mechanisms of Immune Response to Inorganic Nanoparticles and Their Degradation Products
TL;DR: In this paper, the cellular mechanisms of immune response to inorganic nanoparticles and their degradation products with specific focus on immune cells are summarized and a review of factors that need to be considered in the design of safe and effective nanoparticles for use in delivery of bioactive and imaging agents.
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
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Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
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Microsomal lipid peroxidation.
John A. Buege,Steven D. Aust +1 more
TL;DR: This chapter discusses microsomal lipid peroxidation, a complex process known to occur in both plants and animals that involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids.
Journal ArticleDOI
Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.
Journal ArticleDOI
Toxic Potential of Materials at the Nanolevel
TL;DR: The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.