Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes.
Joanna Bloom,Joanna Bloom,Ileana M. Cristea,Andrea L. Procko,Veronica Lubkov,Brian T. Chait,Michael Snyder,Frederick R. Cross +7 more
TLDR
The findings suggest the dephosphorylation of the formins may be important for their observed localization change during exit from mitosis and indicate that Cdc14 targets proteins involved in wide-ranging mitotic events.About:
This article is published in Journal of Biological Chemistry.The article was published on 2011-02-18 and is currently open access. It has received 79 citations till now. The article focuses on the topics: Formins & Mitotic exit.read more
Citations
More filters
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Mass Spectrometry–Based Proteomics and Network Biology
TL;DR: How MS-based proteomics has been applied to network biology to identify the nodes and edges of biological networks, to detect and quantify perturbation-induced network changes, and to correlate dynamic network rewiring with the cellular phenotype is reviewed.
Journal ArticleDOI
Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability
TL;DR: It is shown that the master cell-cycle regulators, cyclin-dependent kinase (Cdk) and Cdc14 phosphatase, control the actions of Yen1, and that uncontrolled Yen1 activity is detrimental to the cell.
Journal ArticleDOI
Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.
TL;DR: Pioneering work from budding yeast is reviewed that has led to a molecular understanding of the establishment and destruction of cohesion, which is central to accurate segregation of chromosomes.
Journal ArticleDOI
Proteomics-based methods for discovery, quantification, and validation of protein-protein interactions.
TL;DR: An understanding of protein functions cannot be fully accomplished without knowledge of its interactions, and characterizing these interactions is critical to understanding the biology of health and disease systems.
References
More filters
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport Mechanism
Michael P. Rout,John D. Aitchison,Adisetyantari Suprapto,Kelly Hjertaas,Yingming Zhao,Brian T. Chait +5 more
TL;DR: In this paper, a comprehensive approach to classify all components of the yeast NPC (nucleoporins) was taken, which involved identifying all the proteins present in a highly enriched NPC fraction, determining which of these proteins were nucleopors, and localizing each nucleoporin within the NPC.
BookDOI
The Cell Cycle
TL;DR: It is shown that the presence of phosphatase inhibitors can have major effects on the levels of phosphorylation and the activities of the kinase extracted from cells, and the combination of okadaic acid and sodium vanadate was most effective in protecting p34cdc2 against cellular phosphatases.
Journal ArticleDOI
Epitope tagging of yeast genes using a PCR‐based strategy: more tags and improved practical routines
Michael Knop,Katja Siegers,Gislene Pereira,Wolfgang Zachariae,Barbara Winsor,Kim Nasmyth,Elmar Schiebel +6 more
TL;DR: In the yeast Saccharomyces cerevisiae, molecular biological techniques have been developed that use a simple PCR‐based strategy to introduce epitope tags to chromosomal loci to produce PCR amplificable modules.
Related Papers (5)
Closing Mitosis: The Functions of the Cdc14 Phosphatase and Its Regulation
Frank Stegmeier,Angelika Amon +1 more