Global Epidemiology of Mucormycosis
TLDR
With the change in epidemiology of mucormycosis country-wise studies are warranted to estimate disease burden in different risk groups, analyse the clinical disease pattern and identify the new etiological agents.Abstract:
Mucormycosis is an angio-invasive fungal infection, associated with high morbidity and mortality. A change in the epidemiology of mucormycosis has been observed in recent years with the rise in incidence, new causative agents and susceptible population. The rise has been perceived globally, but it is very high in the Asian continent. Though diabetes mellitus overshadow all other risk factors in Asia, post-tuberculosis and chronic renal failure have emerged as new risk groups. The rhino-cerebral form of mucormycosis is most commonly seen in patients with diabetes mellitus, whereas, pulmonary mucormycosis in patients with haematological malignancy and transplant recipients. In immunocompetent hosts, cutaneous mucormycosis is commonly seen following trauma. The intriguing clinical entity, isolated renal mucormycosis in immunocompetent patients is only reported from China and India. A new clinical entity, indolent mucormycosis in nasal sinuses, is recently recognized. The causative agents of mucormycosis vary across different geographic locations. Though Rhizopus arrhizus is the most common agent isolated worldwide, Apophysomyces variabilis is predominant in Asia and Lichtheimia species in Europe. The new causative agents, Rhizopus homothallicus, Mucor irregularis, and Thamnostylum lucknowense are reported from Asia. In conclusion, with the change in epidemiology of mucormycosis country-wise studies are warranted to estimate disease burden in different risk groups, analyse the clinical disease pattern and identify the new etiological agents.read more
Citations
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Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India
TL;DR: In this paper, the authors conducted a systematic review of literature to find out the patient's characteristics having mucormycosis and COVID-19, especially from India, and retrieved all the granular details of case reports/series of patients with mucormYcosis, and reported worldwide.
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Epidemiology and Diagnosis of Mucormycosis: An Update
TL;DR: The epidemiology of mucormycosis is evolving as new immunomodulating agents are used in the treatment of cancer and autoimmune diseases, and as the modern diagnostic tools lead to the identification of previously uncommon genera/species such as Apophysomyces or Saksenaea complex.
Journal ArticleDOI
When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis
TL;DR: In this article, the authors reviewed the published COVID-19-associated mucormycosis (CAMCR) cases (total 41) to identify risk factors, clinical features, and outcomes.
Journal ArticleDOI
Multicenter Epidemiologic Study of Coronavirus Disease-Associated Mucormycosis, India.
Atul Patel,Ritesh Agarwal,Shivaprakash M Rudramurthy,Manoj Shevkani,Immaculata Xess,Ratna Sharma,Jayanthi Savio,Nandini Sethuraman,Surabhi Madan,Prakash Shastri,Deepak Thangaraju,Rungmei S. K. Marak,Karuna Tadepalli,Pratik Savaj,Ayesha Sunavala,Neha Gupta,Tanu Singhal,Valliappan Muthu,Arunaloke Chakrabarti +18 more
TL;DR: In this paper, the authors conducted a multicenter retrospective study across India to evaluate epidemiology and outcomes among cases of coronavirus disease (COVID-19)-associated mucormycosis (CAM).
Journal ArticleDOI
A multicentre observational study on the epidemiology, risk factors, management and outcomes of mucormycosis in India
Atul Patel,Atul Patel,Harsimran Kaur,Immaculata Xess,Joy Sarojini Michael,Jayanthi Savio,Shivaprakash M Rudramurthy,Rakesh Singh,Prakash Shastri,P. Umabala,Raman Sardana,Anupama Kindo,Malini R. Capoor,Sangeetha Mohan,Valliappan Muthu,Ritesh Agarwal,Arunaloke Chakrabarti +16 more
TL;DR: Diabetes mellitus was the dominant predisposing factor in all forms of mucormycosis and combined surgical and medical management was associated with better outcomes.
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