Journal ArticleDOI
Glucose and lipid homeostasis in adult rat is impaired by early‐life exposure to perfluorooctane sulfonate
Ziquan Lv,Gengqi Li,Yuanyuan Li,Chenjiang Ying,Jun Chen,Tian Chen,Jie Wei,Yi Lin,Ying Jiang,Youjie Wang,Baihuai Shu,Bing Xu,Shunqing Xu +12 more
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TLDR
It is suggested that developmental exposure to PFOS may contribute to glucose and lipid metabolic disorder in adulthood.Abstract:
Perfluorooctane sulfonate (PFOS), which belongs to the degradation product of many perfluorinated compounds, is on the list of persistent organic pollutants (POPs) and is currently detected in both wildlife and humans. The consequence of gestational and lactational exposure to PFOS on prediabetes effect in offspring was investigated in rats in the present study. Maternal rats were treated with vehicle, 0.5 mg/kg/day or 1.5 mg/kg/day PFOS respectively from gestation day 0 to postnatal day 21. The glucose and lipid metabolism effects were investigated on the offspring in adulthood. The gestational and lactational exposure to PFOS led to low body weight from birth to weaning, and evoked signs of a prediabetic state, with elevated fasting serum insulin and leptin level, impaired glucose tolerance, though the fasting serum glucose and glycosylated serum protein level were normal. Abnormal lipid homeostasis was also observed by the phenomenon of hepatic steatosis and increased gonadal fat pad weight. However, the circulating serum level of fasting triglyceride and cholesterol level were no different from controls. Our results suggested that developmental exposure to PFOS may contribute to glucose and lipid metabolic disorder in adulthood.read more
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Metabolism disrupting chemicals and metabolic disorders
Jerrold J. Heindel,Bruce Blumberg,Mathew C. Cave,Ronit Machtinger,Alberto Mantovani,Michelle A. Mendez,Angel Nadal,Paola Palanza,Giancarlo Panzica,Robert M. Sargis,Laura N. Vandenberg,Frederick S. vom Saal +11 more
TL;DR: This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders.
Journal ArticleDOI
Per- and polyfluorinated substances (PFASs): Environmental challenges
TL;DR: In this article, the authors show that long-chain perfluoroalkylated acids are persistent in the environment, leading to ubiquitous exposure of biota, and they have been listed as very persistent, very bioaccumulative and toxic by Public Health Authorities.
Journal ArticleDOI
Electrochemical oxidation of perfluorinated compounds in water
TL;DR: Although the ultrasonication and hydrothermal techniques combined with the EO process can improve the removal efficiency and current efficiency significantly, these coupled techniques have not been commercialized and applied in industrial wastewater treatment.
Journal ArticleDOI
PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.
Mitchell B. Rosen,Kaberi P. Das,John P. Rooney,Barbara D. Abbott,Christopher Lau,J. Christopher Corton +5 more
TL;DR: Predictive gene expression biomarkers showed that PFAAs activate CAR in both genotypes and cause feminization of the liver transcriptome through suppression of signal transducer and activator of transcription 5B (STAT5B).
Journal ArticleDOI
Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among U.S. Women
Qi Sun,Geng Zong,Damaskini Valvi,Flemming Nielsen,Brent A. Coull,Philippe Grandjean,Philippe Grandjean +6 more
TL;DR: Background exposures to PFASs in the late 1990s were associated with higher T2D risk during the following years in a prospective case–control study of women from the NHSII, and these findings support a potential diabetogenic effect of PFAS exposures.
References
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Effect of In Utero and Early-Life Conditions on Adult Health and Disease
TL;DR: Evidence from several disciplines is synthesized to support the contention that environmental factors acting during development should be accorded greater weight in models of disease causation.
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Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Kikuko Hotta,Tohru Funahashi,Yukio Arita,Masahiko Takahashi,Morihiro Matsuda,Yoshihisa Okamoto,Hiromi Iwahashi,Hiroshi Kuriyama,Noriyuki Ouchi,Kazuhisa Maeda,Makoto Nishida,Shinji Kihara,Naohiko Sakai,Tadahisa Nakajima,Kyoichi Hasegawa,Masahiro Muraguchi,Yasukazu Ohmoto,Tadashi Nakamura,Shizuya Yamashita,Toshiaki Hanafusa,Yuji Matsuzawa +20 more
TL;DR: Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.
Journal ArticleDOI
Fetal and infant growth and impaired glucose tolerance at age 64.
C. N. Hales,David J.P. Barker,Penelope M.S. Clark,Lorna Cox,Caroline H.D. Fall,Clive Osmond,P D Winter +6 more
TL;DR: Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes and reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction.
Journal ArticleDOI
Lipid extraction of tissues with a low-toxicity solvent
Atsushi Hara,Norman S. Radin +1 more
TL;DR: An improved method for extracting the lipids from tissues consists of the use of hexane:isopropanol, followed by a wash of the extract with aqueous sodium sulfate to remove nonlipid contaminants.
Journal ArticleDOI
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Christopher Lau,Katherine Anitole,Colette Hodes,David Y. Lai,Andrea Pfahles-Hutchens,Jennifer Seed +5 more
TL;DR: An overview of the recent advances in the toxicology and mode of action for PFAAs, and of the monitoring data now available for the environment, wildlife, and humans is provided.