Journal ArticleDOI
'Go or grow': the key to the emergence of invasion in tumour progression?
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TLDR
It is proposed that the transition to invasive tumour phenotypes can be explained on the basis of the microscopic 'Go or Grow' mechanism (migration/proliferation dichotomy) and the oxygen shortage, i.e. hypoxia, in the environment of a growing tumour.Abstract:
Uncontrolled proliferation and abnormal cell migration are two of the main characteristics of tumour growth. Of ultimate importance is the question what are the mechanisms that trigger the progression from benign neoplasms (uncontrolled/autonomous proliferation) to malignant invasive tumours (high migration). In the following, we challenge the currently prevailing view that the emergence of invasiveness is mainly the consequence of acquired cancer cell mutations. To study this, we mainly focus on the 'glioblastoma multiforme' (GBM) tumour which is a particularly aggressive and invasive tumour. In particular, with the help of a simple growth model, we demonstrate that the short time required for the recurrence of a GBM tumour after a gross total resection cannot be deduced solely from a mutation-based theory. We propose that the transition to invasive tumour phenotypes can be explained on the basis of the microscopic 'Go or Grow' mechanism (migration/proliferation dichotomy) and the oxygen shortage, i.e. hypoxia, in the environment of a growing tumour. We test this hypothesis with the help of a lattice-gas cellular automaton. Finally, we suggest possible therapies that could help prevent the progression towards malignancy and invasiveness of benign tumours.read more
Citations
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Journal ArticleDOI
The mathematics of cancer: integrating quantitative models
TL;DR: The recent expansion of quantitative models addresses many questions regarding tumour initiation, progression and metastases as well as intra-tumour heterogeneity, treatment responses and resistance.
Journal ArticleDOI
Tumor Budding: The Name is EMT. Partial EMT.
TL;DR: Based on recent literature, indicating a co-expression of epithelial and mesenchymal markers in many tumor buds, it is posited that tumor budding is a manifestation of this hybrid epithelial/mesenchyal phenotype displaying collective cell migration.
Journal ArticleDOI
A Review of Cell-Based Computational Modeling in Cancer Biology.
TL;DR: This review introduces the broad range of techniques available for cell-based computational modeling and illustrates these methods with examples drawn from cancer hypoxia, angiogenesis, invasion, stem cells, and immunosurveillance.
Journal ArticleDOI
Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes.
TL;DR: A hybrid multiscale mathematical model of tumor growth in vascularized tissue is investigated, highlighting the risks of cytotoxic and antiangiogenic treatments in the context of tumor heterogeneity resulting from a selection for more aggressive behaviors.
Journal ArticleDOI
Global Weak Solutions in a PDE-ODE System Modeling Multiscale Cancer Cell Invasion
TL;DR: It is proved the global existence, along with some basic boundedness properties, of weak solutions to a PDE-ODE system modeling the multiscale invasion of tumor cells through the surrounding tissue matrix.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Why do cancers have high aerobic glycolysis
TL;DR: In this article, the authors propose that persistent metabolism of glucose to lactate even in aerobic conditions is an adaptation to intermittent hypoxia in pre-malignant lesions, which leads to microenvironmental acidosis requiring evolution to phenotypes resistant to acid-induced cell toxicity.
Journal ArticleDOI
Cancer as an evolutionary and ecological process.
TL;DR: The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer.
Journal ArticleDOI
Cost of Migration: Invasion of Malignant Gliomas and Implications for Treatment
TL;DR: In this paper, the authors discuss mechanisms of glioma invasion, characteristics of the invasive cell, and consequences of this cellular phenotype for surgical resection, oncologic treatments, and future perspectives for anti-invasive strategies.
Book
Cellular automata modeling of physical systems
Bastien Chopard,Michel Droz +1 more
TL;DR: Cellular automata modeling helps clarify the mechanics of lattice gas phenomena and provides insights into reaction-diffusion processes and their applications.
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