Journal ArticleDOI
Growth differentiation factor 15 promotes cell viability, invasion, migration, and angiogenesis in human liver carcinoma cell line HepG2.
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TLDR
GDF15 could promote cell viability, invasion, migration, and angiogenesis of HepG2 cells and might be a potential risk factor of HCC.About:
This article is published in Clinics and Research in Hepatology and Gastroenterology.The article was published on 2017-09-01. It has received 20 citations till now. The article focuses on the topics: Viability assay & Angiogenesis.read more
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Journal ArticleDOI
Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion.
Teresa Arnandis,Pedro Monteiro,Sophie D. Adams,Victoria L. Bridgeman,Vinothini Rajeeve,Emanuela Gadaleta,Jacek Marzec,Claude Chelala,Ilaria Malanchi,Pedro R. Cutillas,Susana A. Godinho +10 more
TL;DR: It is shown that supernumerary centrosomes induce a paracrine-signaling axis via the secretion of proteins, including interleukin-8 (IL-8), which leads to non-cell-autonomous invasion in 3D mammary organoids and zebrafish models and demonstrates that centrosome amplification induces an early oxidative stress response via increased NOX-generated reactive oxygen species (ROS), which mediates secretion of pro-invasive factors.
Journal ArticleDOI
Roles of Growth Differentiation Factor 15 in Atherosclerosis and Coronary Artery Disease
TL;DR: GDF‐15, a stress‐responsive member of the transforming growth factor‐β (TGF‐β) cytokine superfamily, has been shown to be a strong and independent predictor of mortality and disease progression in patients with atherosclerosis and coronary artery disease (CAD), such as acute coronary syndromes (ACS) and stable angina pectoris.
Journal ArticleDOI
Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease.
Judith J. de Haan,Saskia Haitjema,Hester M. den Ruijter,Gerard Pasterkamp,Gert J. de Borst,Martin Teraa,Marianne C. Verhaar,Hendrik Gremmels,Saskia C.A. de Jager +8 more
TL;DR: High GDF15 levels are associated with increased risk of major amputation and/or death in PAD patients, and could be of additive value to identify patients who are at high risk of amputation or death and could help guide treatment choices.
Journal ArticleDOI
Metformin is the key factor in elevated plasma growth differentiation factor‐15 levels in type 2 diabetes: A nested, case–control study
Andrea Natali,Lorenzo Nesti,Elena Venturi,Angela C. Shore,Faisel Khan,Kim M. Gooding,Phillip E. Gates,Helen C. Looker,Fiona Dove,Isabel Gonçalves,Margaretha Persson,Jan Nilsson +11 more
TL;DR: In participants with diabetes, metformin treatment was associated with a 40% rise in GDF‐15 level, which was independent of the other major factors, and largely explained their elevated GDF•15 levels, which might partly explain the protective cardiovascular effects of met formin.
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microRNA-16 Via Twist1 Inhibits EMT Induced by PM2.5 Exposure in Human Hepatocellular Carcinoma.
Hao Zhang,Zhihu Li +1 more
TL;DR: The present study confirmed the pro-proliferative and pro-metastatic effect of PM2.5 on HCC cell line SMMC-7721 and explored the underlying mechanisms.
References
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Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors
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Cyclooxygenase Inhibitors Regulate the Expression of a TGF-β Superfamily Member That Has Proapoptotic and Antitumorigenic Activities
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